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• W1980021265 abstract "Some children with chronic cholestasis require courses of parenteral nutrition, which comprise lipid emulsions to provide energy. We aimed to see what was the influence of parenterally infused lipids- LCT or MCT/LCT on bilirubin levels, plasma lipids, lipoproteins and polyunsaturated fatty acids (PUFA) in HDL phospholipids. We investigated 9 infants with chronic cholestasis (2 - Byler's disease, 2-biliary atresia, 1- α1- antitrypsin deficiency, 4- intrahepatic cholestasis of unknow origin). Each child was infused (next to glucose, amino acids) twice with two different lipid infusions with a dose of 2 g triglycerides /kg bodyweight & day for 3 days each one: LCT and MCT/LCT (50%/50%) lipid infusion (lipid infusion was discontinued for min. 3 days between these infusions). We measured the following parameters at baseline, at the end of lipid infusion on 3rd day and 6h later: bilirubin levels, plasma cholesterol (Ch), triglyceride(TG) and (PI) concentrations (conc.) as well as TG, Ch and PI in lipoproteins (LDL, HDL, VLDL, chylomicrone-like fraction) and fatty acid profile in HDL phospholipids (%wt/wt). Results: The significant decline of serum bilirubin was observed 6 h after LCT infusion compared to baseline values (7,8±1.8 mg/dl vs. 8,5±2.0; [mean ± SE]; p< 0.05) and after MCT/LCT infusion (7,1±6,5 vs. 7,9±6,5; p< 0.05). Plasma Ch, TG, PI conc. at the end of lipid infusion did not differ from the baseline values under LCT (Ch: 239±51mg/dl vs. 243 ±70; TG: 117±24 mg/dl vs. 122±33; PI: 392±103 mg/dl vs. 353±115) and also under MCT/LCT infusion (Ch: 233±44 vs. 230±65; TG: 145±41 vs. 102±12; PI: 366±87 vs. 355±117). Similarly there were no changes of Ch, TG and PI in HDL, LDL, VLDL and chylomicrones during LCT or MCT/LCT infusion. The PUFA content increased during LCT (from 29,8±0,9 to 35,9±1,4) and MCT/LCT infusion (from 30,4±1,0 to 33,0 ±0,7) that was accompanied by significant rise of linoleic acid (LA; 14.1±0.6 to 19.9±0.8; P<0.01), α-linolenic acid (0.20±0.05 to 0.36±0.05; P<0.01) and docosahexaenoic acid (2.0±0.2 to 2.5±0.3) under LCT and significant rise of LA (14.3±0.5 to 16.7±0.5) and arachidonic acid (7.5±0.4 to 7.9±0.4) under MCT/LCT. Conclusions: 1. Infants with chronic cholestasis have a good metabolic tolerance of intravenously infused lipids: MCT/LCT or LCT. 2. Both lipid infusions provide PUFA but plasma rise of PUFA is more significant with LCT. 3. Short term lipid infusion appears to be safe in infantile cholestasis." @default.
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• W1980021265 date "1997-04-01" @default.
• W1980021265 modified "2023-09-25" @default.
• W1980021265 title "MCT/LCT OR LCT LIPID INFUSIONS IN INFANTS WITH CHRONIC CHOLESTASIS" @default.
• W1980021265 doi "https://doi.org/10.1097/00005176-199704000-00171" @default.
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