Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980046832> ?p ?o ?g. }
- W1980046832 endingPage "797" @default.
- W1980046832 startingPage "765" @default.
- W1980046832 abstract "Indoleamine 2,3-dioxygenase (IDO) is a natural mechanism of creating acquired tolerance in a variety of physiological settings. This endogenous tolerogenic pathway has important functions in regulating the magnitude of immune responses in settings of infection, pregnancy, tissue transplantation, mucosal interfaces and others. Whether for angiogenesis, stromal formation or immunologic tolerance, tumors often rely on recruiting host mechanisms. IDO is one such potent endogenous mechanism that appears to be frequently hijacked by tumors to establish systemic immune tolerance to tumor antigens. IDO can be expressed by tumors themselves, but, in addition, its natural site of expression is the host immune cells recruited by the tumor (particularly dendritic cells and macrophages). Therapeutic strategies that target the IDO pathway have been shown to synergize with standard chemotherapy and experimental immunotherapies to break tumor-induced tolerance. When such strategies target IDO expressed in host cells, they may be able to disrupt tolerance without creating intrinsic tumor cell drug resistance." @default.
- W1980046832 created "2016-06-24" @default.
- W1980046832 creator A5011462362 @default.
- W1980046832 creator A5033744020 @default.
- W1980046832 date "2012-08-01" @default.
- W1980046832 modified "2023-10-14" @default.
- W1980046832 title "Host Indoleamine 2,3-Dioxygenase: Contribution to Systemic Acquired Tumor Tolerance" @default.
- W1980046832 cites W1499565330 @default.
- W1980046832 cites W1529961505 @default.
- W1980046832 cites W1554937135 @default.
- W1980046832 cites W1585166895 @default.
- W1980046832 cites W1592933330 @default.
- W1980046832 cites W1603640418 @default.
- W1980046832 cites W1622259963 @default.
- W1980046832 cites W168107337 @default.
- W1980046832 cites W1754929897 @default.
- W1980046832 cites W1833987578 @default.
- W1980046832 cites W1834981029 @default.
- W1980046832 cites W1859810431 @default.
- W1980046832 cites W1881296535 @default.
- W1980046832 cites W1903872164 @default.
- W1980046832 cites W1931474344 @default.
- W1980046832 cites W1947375451 @default.
- W1980046832 cites W1964282557 @default.
- W1980046832 cites W1964709968 @default.
- W1980046832 cites W1971360146 @default.
- W1980046832 cites W1971420166 @default.
- W1980046832 cites W1972137566 @default.
- W1980046832 cites W1973210209 @default.
- W1980046832 cites W1973251492 @default.
- W1980046832 cites W1976707323 @default.
- W1980046832 cites W1977692898 @default.
- W1980046832 cites W1977753547 @default.
- W1980046832 cites W1977831876 @default.
- W1980046832 cites W1977955576 @default.
- W1980046832 cites W1981575054 @default.
- W1980046832 cites W1983664228 @default.
- W1980046832 cites W1983923482 @default.
- W1980046832 cites W1986144146 @default.
- W1980046832 cites W1987171603 @default.
- W1980046832 cites W1987772726 @default.
- W1980046832 cites W1988877663 @default.
- W1980046832 cites W1988941798 @default.
- W1980046832 cites W1989044153 @default.
- W1980046832 cites W1991075838 @default.
- W1980046832 cites W1991243877 @default.
- W1980046832 cites W1991344565 @default.
- W1980046832 cites W1991359561 @default.
- W1980046832 cites W1991392411 @default.
- W1980046832 cites W1998142996 @default.
- W1980046832 cites W1998932146 @default.
- W1980046832 cites W1999028733 @default.
- W1980046832 cites W1999601075 @default.
- W1980046832 cites W2000725338 @default.
- W1980046832 cites W2001678293 @default.
- W1980046832 cites W2003303180 @default.
- W1980046832 cites W2003635644 @default.
- W1980046832 cites W2003810822 @default.
- W1980046832 cites W2004440284 @default.
- W1980046832 cites W2004522121 @default.
- W1980046832 cites W2004630197 @default.
- W1980046832 cites W2007569529 @default.
- W1980046832 cites W2007749861 @default.
- W1980046832 cites W2008249034 @default.
- W1980046832 cites W2010343273 @default.
- W1980046832 cites W2010378562 @default.
- W1980046832 cites W2012416768 @default.
- W1980046832 cites W2013729937 @default.
- W1980046832 cites W2014545440 @default.
- W1980046832 cites W2014590681 @default.
- W1980046832 cites W2015260577 @default.
- W1980046832 cites W2018234318 @default.
- W1980046832 cites W2018458005 @default.
- W1980046832 cites W2018769352 @default.
- W1980046832 cites W2020427416 @default.
- W1980046832 cites W2021366252 @default.
- W1980046832 cites W2022369681 @default.
- W1980046832 cites W2022430924 @default.
- W1980046832 cites W2024000351 @default.
- W1980046832 cites W2026429388 @default.
- W1980046832 cites W2027821655 @default.
- W1980046832 cites W2028575737 @default.
- W1980046832 cites W2030923896 @default.
- W1980046832 cites W2031585195 @default.
- W1980046832 cites W2032029407 @default.
- W1980046832 cites W2032490555 @default.
- W1980046832 cites W2032977462 @default.
- W1980046832 cites W2037920661 @default.
- W1980046832 cites W2038163944 @default.
- W1980046832 cites W2038234028 @default.
- W1980046832 cites W2039769611 @default.
- W1980046832 cites W2040636315 @default.
- W1980046832 cites W2041162007 @default.
- W1980046832 cites W2041808941 @default.
- W1980046832 cites W2042219548 @default.
- W1980046832 cites W2043752997 @default.
- W1980046832 cites W2045293532 @default.
- W1980046832 cites W2046505430 @default.