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• W1980052057 startingPage "1225" @default.
• W1980052057 abstract "Tourette syndrome, a chronic tic disorder with autosomal dominant inheritance, exhibits considerable phenotypic variability even within monozygotic twin pairs. The origins of this variability remain unclear. Recent findings have implicated the caudate nucleus as a locus of pathology, and pharmacological evidence supports dopaminergic involvement. Within monozygotic twins discordant for Tourette syndrome severity, differences in D2 dopamine receptor binding in the head of the caudate nucleus predicted differences in phenotypic severity (r = 0.99); this relation was not observed in putamen. These data may link Tourette syndrome with a spectrum of neuropsychiatric disorders that involve associative striatal circuitry." @default.
• W1980052057 created "2016-06-24" @default.
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• W1980052057 date "1996-08-30" @default.
• W1980052057 modified "2023-09-25" @default.
• W1980052057 title "Tourette Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding" @default.
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• W1980052057 doi "https://doi.org/10.1126/science.273.5279.1225" @default.
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