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• W1980056186 endingPage "1266" @default.
• W1980056186 startingPage "1260" @default.
• W1980056186 abstract "Tannic acid is a hydrolyzable tannin that exists in many widespread edible plants with a variety of biological activities. In this study, we found that tannic acid potently inhibited the activity of fatty acid synthase (FAS) in a concentration-dependent manner with a half-inhibitory concentration value (IC50) of 0.14 μM. The inhibition kinetic results showed that the inhibition of FAS by tannic acid was mixed competitive and noncompetitive manner with respect to acetyl-CoA and malonyl-CoA, but uncompetitive to NADPH. Tannic acid prevented the differentiation of 3T3-L1 pre-adipocytes, and thus repressed intracellular lipid accumulation. In the meantime, tannic acid decreased the expression of FAS and down-regulated the mRNA level of FAS and PPARγ during adipocyte differentiation. Further studies showed that the inhibitory effect of tannic acid did not relate to FAS non-specific sedimentation. Since FAS was believed to be a therapeutic target of obesity, these findings suggested that tannic acid was considered having potential in the prevention of obesity." @default.
• W1980056186 created "2016-06-24" @default.
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• W1980056186 date "2013-07-01" @default.
• W1980056186 modified "2023-10-16" @default.
• W1980056186 title "Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte" @default.
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• W1980056186 doi "https://doi.org/10.1016/j.bbalip.2013.04.003" @default.
• W1980056186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24046866" @default.
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