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• W1980058356 endingPage "11646" @default.
• W1980058356 startingPage "11642" @default.
• W1980058356 abstract "Each G protein-coupled receptor recognizes only a distinct subset of the many structurally closely related G proteins expressed within a cell. How this selectively is achieved at a molecular level is not well understood, particularly since no specific point-to-point contact sites between a receptor and its cognate G protein(s) have been identified. In this study, we demonstrate that a 4-aa epitope on the m2 muscarinic acetylcholine receptor, a prototypical Gi/o-coupled receptor, can specifically recognize the C-terminal 5 aa of alpha subunits of the Gi/o protein family. The m2 receptor residues involved in this interaction are predicted to be located on one side of an alpha-helical receptor region present at the junction between the third intracellular loop and the sixth transmembrane domain. Coexpression studies with hybrid m2/m3 muscarinic receptors and mutant G-protein alpha q subunits showed that the receptor/G-protein contact site identified in this study is essential for coupling specificity and G-protein activation." @default.
• W1980058356 created "2016-06-24" @default.
• W1980058356 creator A5015095365 @default.
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• W1980058356 date "1995-12-05" @default.
• W1980058356 modified "2023-10-01" @default.
• W1980058356 title "Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation." @default.
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• W1980058356 doi "https://doi.org/10.1073/pnas.92.25.11642" @default.
• W1980058356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/40458" @default.
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• W1980058356 hasPublicationYear "1995" @default.
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