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- W1980092008 abstract "Viable yellow obese mice (Avy/a) were treated for 10 days with 5, 15, 50 or 150 ug/d of either alpha-MSH or desacetyl-MSH. The half-maximal effect on weight gain occurred with a dose of 5 ug/d for desacetyl-MSH and at a 30 fold higher level of 150 ug/d for alpha-MSH. In contrast, the half-maximal stimulation of eumelanin production by alpha-MSH occurred at 15 ug/d and with desacetyl-MSH at 150 ug/d, a 10-fold increase. Desacetyl-MSH produced a dose-related increase in the weight of muscle, as well as white and brown adipose tissue. Desacetyl-MSH and alpha-MSH both increased plasma corticosterone concentrations, but desacetyl-MSH was more potent. In a 2×2 factorial designed study, body weight was significantly increased in viable yellow mice only by treatment with desacetyl-MSH but in the lean animals, both alpha-MSH and desacetyl-MSH increased body weight. Food intake was significantly different between genotypes, and was stimulated by desacetyl-MSH. These studies demonstrate potent differences in biological actions on food intake, body weight, and a variety of organ weights between acetylated and desacetylated forms of MSH." @default.
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- W1980092008 date "1989-01-01" @default.
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- W1980092008 title "Effects of MSH on food intake, body weight and coat color of the yellow obese mouse" @default.
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- W1980092008 doi "https://doi.org/10.1016/0024-3205(89)90105-7" @default.
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