FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980093407> ?p ?o ?g. }

• W1980093407 endingPage "230" @default.
• W1980093407 startingPage "230.2" @default.
• W1980093407 abstract "<h3>Background</h3> GCA is a chronic inflammatory disease involving large and medium-sized arteries. It is considered the most frequent primary vasculitis with higher incidence in women. Mean age of onset in different cohorts ranges between 72-74 years. Former studies have observed certain differences in GCA clinical spectrum depending on age at disease presentation and gender. Particularly polymyalgia rheumatica has been found to be more frequent in women and in patients younger than 70 years. <h3>Objectives</h3> The purpose of this study was to evaluate differences in initial clinical manifestations, ischemic complications and clinical course according to age at onset and gender in a prospectively followed cohort of patients with biopsy-proven giant cell arteritis. <h3>Methods</h3> Between 1995 and 2005, 170 patients were diagnosed with biopsy proven GCA at our institution. Among them, 94 patients were selected according to the following criteria: prospective treatment by the authors according to uniform criteria, prospective periodic screening for aneurysm, prospective recording of GCA presentation, ischemic complications, relapses, glucocorticosteroid doses, and follow-up duration of at least 4 years. Based on the mean ± standard deviation (SD) of age at disease onset, patients were classified in 3 groups: age equal or below 67 years (mean -1SD) (early onset, n=16), age between 68 and 80 years (n=57), and age equal or older than 81 (mean+1SD) (late onset, n=21). Although retrospective in design, the study was performed on a prospectively followed cohort. Chi-square test, ANOVA test and Kaplan-Meyer survival analysis/log-rank test were used for statistical comparison. <h3>Results</h3> Mean age (±SD) at diagnosis w as 74±7 years (58-89). Patients with early onset GCA (≤67 years) presented more frequently fever (p=0.002), and had higher erythrocyte sedimentation rate (0.039) than patients >68 years. In contrast, late onset GCA (≥81 years) was characterized by higher prevalence of severe ischemic complications in the form of amaurosis fugax (6% for ≤67 years vs 9% for 68-80 vs 29% for ≥81 years, p=0.046) and blindness (6% for ≤67 years vs 7% for 68-80 vs 33% for ≥81 years, p=0.006). During follow-up, late onset GCA patients relapsed less frequently (p=0.027). Concerning to gender, we found no differences in the initial clinical presentation between men and women but men developed more frequently aortic aneurysm during follow-up (p=0.003). <h3>Conclusions</h3> Age at onset and gender are associated with differences in clinical presentation and outcome in patients with GCA. <h3>References</h3> Narvaez J, Nolla-Sole JM, Valverde-Garcia J, Roig-Escofet D. Sex differences in temporal arteritis and polymyalgia rheumatica. J Rheumatol. 2002;29(2):321-5. Lopez-Diaz MJ, Llorca J, Gonzalez-Juanatey C, Pena-Sagredo JL, Martin J, Gonzalez-Gay MA. Implication of the age in the clinical spectrum of giant cell arteritis. Clin Exp Rheumatol. 2008;26(3 Suppl 49):S16-22. Nir-Paz R, Gross A, Chajek-Shaul T. Sex differences in giant cell arteritis. J Rheumatol. 2002;29(6):1219-23. <h3>Disclosure of Interest</h3> None Declared" @default.
• W1980093407 created "2016-06-24" @default.
• W1980093407 creator A5000989837 @default.
• W1980093407 creator A5047090354 @default.
• W1980093407 creator A5057067776 @default.
• W1980093407 creator A5058752155 @default.
• W1980093407 creator A5059764745 @default.
• W1980093407 creator A5079912215 @default.
• W1980093407 creator A5081321895 @default.
• W1980093407 date "2013-06-01" @default.
• W1980093407 modified "2023-10-18" @default.
• W1980093407 title "THU0222 Differences in clinical presentation and outcome in patients with early versus late onset giant-cell arteritis (GCA): Analysis of 94 patients" @default.
• W1980093407 doi "https://doi.org/10.1136/annrheumdis-2012-eular.2187" @default.
• W1980093407 hasPublicationYear "2013" @default.
• W1980093407 type Work @default.
• W1980093407 sameAs 1980093407 @default.
• W1980093407 citedByCount "1" @default.
• W1980093407 countsByYear W19800934072013 @default.
• W1980093407 crossrefType "journal-article" @default.
• W1980093407 hasAuthorship W1980093407A5000989837 @default.
• W1980093407 hasAuthorship W1980093407A5047090354 @default.
• W1980093407 hasAuthorship W1980093407A5057067776 @default.
• W1980093407 hasAuthorship W1980093407A5058752155 @default.
• W1980093407 hasAuthorship W1980093407A5059764745 @default.
• W1980093407 hasAuthorship W1980093407A5079912215 @default.
• W1980093407 hasAuthorship W1980093407A5081321895 @default.
• W1980093407 hasConcept C120665830 @default.
• W1980093407 hasConcept C121332964 @default.
• W1980093407 hasConcept C126322002 @default.
• W1980093407 hasConcept C141071460 @default.
• W1980093407 hasConcept C167135981 @default.
• W1980093407 hasConcept C187212893 @default.
• W1980093407 hasConcept C188816634 @default.
• W1980093407 hasConcept C2776015282 @default.
• W1980093407 hasConcept C2776712624 @default.
• W1980093407 hasConcept C2777767895 @default.
• W1980093407 hasConcept C2779134260 @default.
• W1980093407 hasConcept C2780079024 @default.
• W1980093407 hasConcept C2781343717 @default.
• W1980093407 hasConcept C61511704 @default.
• W1980093407 hasConcept C71924100 @default.
• W1980093407 hasConcept C72563966 @default.
• W1980093407 hasConceptScore W1980093407C120665830 @default.
• W1980093407 hasConceptScore W1980093407C121332964 @default.
• W1980093407 hasConceptScore W1980093407C126322002 @default.
• W1980093407 hasConceptScore W1980093407C141071460 @default.
• W1980093407 hasConceptScore W1980093407C167135981 @default.
• W1980093407 hasConceptScore W1980093407C187212893 @default.
• W1980093407 hasConceptScore W1980093407C188816634 @default.
• W1980093407 hasConceptScore W1980093407C2776015282 @default.
• W1980093407 hasConceptScore W1980093407C2776712624 @default.
• W1980093407 hasConceptScore W1980093407C2777767895 @default.
• W1980093407 hasConceptScore W1980093407C2779134260 @default.
• W1980093407 hasConceptScore W1980093407C2780079024 @default.
• W1980093407 hasConceptScore W1980093407C2781343717 @default.
• W1980093407 hasConceptScore W1980093407C61511704 @default.
• W1980093407 hasConceptScore W1980093407C71924100 @default.
• W1980093407 hasConceptScore W1980093407C72563966 @default.
• W1980093407 hasIssue "Suppl 3" @default.
• W1980093407 hasLocation W19800934071 @default.
• W1980093407 hasOpenAccess W1980093407 @default.
• W1980093407 hasPrimaryLocation W19800934071 @default.
• W1980093407 hasRelatedWork W171063159 @default.
• W1980093407 hasRelatedWork W1980093407 @default.
• W1980093407 hasRelatedWork W2094835078 @default.
• W1980093407 hasRelatedWork W2125206659 @default.
• W1980093407 hasRelatedWork W2556097837 @default.
• W1980093407 hasRelatedWork W2945390134 @default.
• W1980093407 hasRelatedWork W3034592581 @default.
• W1980093407 hasRelatedWork W3093545047 @default.
• W1980093407 hasRelatedWork W41306715 @default.
• W1980093407 hasRelatedWork W4304758360 @default.
• W1980093407 hasVolume "71" @default.
• W1980093407 isParatext "false" @default.
• W1980093407 isRetracted "false" @default.
• W1980093407 magId "1980093407" @default.
• W1980093407 workType "article" @default.