Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980095812> ?p ?o ?g. }
- W1980095812 endingPage "512" @default.
- W1980095812 startingPage "501" @default.
- W1980095812 abstract "Localization of Ste5 to GP at the plasma membrane is essential for transmission of the pheromone signal to associated MAP kinase cascade enzymes. Here, we show that this crucial localization requires prior shuttling of Ste5 through the nucleus. Ste5 shuttles through the nucleus constitutively during vegetative growth. Pheromone enhances nuclear export of Ste5, and this pool translocates vectorially to the cell periphery. Remarkably, Ste5 that cannot transit the nucleus is unable to localize at the periphery and activate the pathway, while Ste5 with enhanced transit through the nucleus has enhanced ability to localize to the periphery and activate the pathway. This novel regulatory scheme may ensure that cytoplasmic Ste5 does not activate downstream kinases in the absence of pheromone and could be applicable to other membrane-recruited signaling proteins." @default.
- W1980095812 created "2016-06-24" @default.
- W1980095812 creator A5009350847 @default.
- W1980095812 creator A5012175613 @default.
- W1980095812 creator A5026075995 @default.
- W1980095812 creator A5038211445 @default.
- W1980095812 date "1999-08-01" @default.
- W1980095812 modified "2023-09-27" @default.
- W1980095812 title "Nuclear Shuttling of Yeast Scaffold Ste5 Is Required for Its Recruitment to the Plasma Membrane and Activation of the Mating MAPK Cascade" @default.
- W1980095812 cites W1500815560 @default.
- W1980095812 cites W1503088063 @default.
- W1980095812 cites W1520947267 @default.
- W1980095812 cites W1521764524 @default.
- W1980095812 cites W1534920118 @default.
- W1980095812 cites W1911465857 @default.
- W1980095812 cites W1911914208 @default.
- W1980095812 cites W1963525943 @default.
- W1980095812 cites W1963705823 @default.
- W1980095812 cites W1966767622 @default.
- W1980095812 cites W1969288614 @default.
- W1980095812 cites W1969419107 @default.
- W1980095812 cites W1971571944 @default.
- W1980095812 cites W1983728585 @default.
- W1980095812 cites W1991760443 @default.
- W1980095812 cites W1994148031 @default.
- W1980095812 cites W1995531673 @default.
- W1980095812 cites W2006783888 @default.
- W1980095812 cites W2015692715 @default.
- W1980095812 cites W2015851068 @default.
- W1980095812 cites W2035764871 @default.
- W1980095812 cites W2042541583 @default.
- W1980095812 cites W2044797210 @default.
- W1980095812 cites W2053796273 @default.
- W1980095812 cites W2054388798 @default.
- W1980095812 cites W2058976160 @default.
- W1980095812 cites W2060232163 @default.
- W1980095812 cites W2060742513 @default.
- W1980095812 cites W2064018568 @default.
- W1980095812 cites W2064352971 @default.
- W1980095812 cites W2079990775 @default.
- W1980095812 cites W2080565111 @default.
- W1980095812 cites W2083908135 @default.
- W1980095812 cites W2084952038 @default.
- W1980095812 cites W2085816650 @default.
- W1980095812 cites W2089330962 @default.
- W1980095812 cites W2093586327 @default.
- W1980095812 cites W2117669008 @default.
- W1980095812 cites W2117986762 @default.
- W1980095812 cites W2124923437 @default.
- W1980095812 cites W2137035181 @default.
- W1980095812 cites W2144784260 @default.
- W1980095812 cites W2151981938 @default.
- W1980095812 cites W2155154794 @default.
- W1980095812 cites W2165856891 @default.
- W1980095812 cites W2166731355 @default.
- W1980095812 cites W2170631106 @default.
- W1980095812 cites W2171159525 @default.
- W1980095812 cites W2181380647 @default.
- W1980095812 cites W243361401 @default.
- W1980095812 cites W976139268 @default.
- W1980095812 doi "https://doi.org/10.1016/s0092-8674(00)81978-9" @default.
- W1980095812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10481914" @default.
- W1980095812 hasPublicationYear "1999" @default.
- W1980095812 type Work @default.
- W1980095812 sameAs 1980095812 @default.
- W1980095812 citedByCount "149" @default.
- W1980095812 countsByYear W19800958122012 @default.
- W1980095812 countsByYear W19800958122013 @default.
- W1980095812 countsByYear W19800958122014 @default.
- W1980095812 countsByYear W19800958122015 @default.
- W1980095812 countsByYear W19800958122016 @default.
- W1980095812 countsByYear W19800958122017 @default.
- W1980095812 countsByYear W19800958122019 @default.
- W1980095812 countsByYear W19800958122020 @default.
- W1980095812 countsByYear W19800958122022 @default.
- W1980095812 countsByYear W19800958122023 @default.
- W1980095812 crossrefType "journal-article" @default.
- W1980095812 hasAuthorship W1980095812A5009350847 @default.
- W1980095812 hasAuthorship W1980095812A5012175613 @default.
- W1980095812 hasAuthorship W1980095812A5026075995 @default.
- W1980095812 hasAuthorship W1980095812A5038211445 @default.
- W1980095812 hasBestOaLocation W19800958121 @default.
- W1980095812 hasConcept C184235292 @default.
- W1980095812 hasConcept C190062978 @default.
- W1980095812 hasConcept C2780723820 @default.
- W1980095812 hasConcept C53645450 @default.
- W1980095812 hasConcept C57074206 @default.
- W1980095812 hasConcept C62478195 @default.
- W1980095812 hasConcept C86803240 @default.
- W1980095812 hasConcept C95444343 @default.
- W1980095812 hasConceptScore W1980095812C184235292 @default.
- W1980095812 hasConceptScore W1980095812C190062978 @default.
- W1980095812 hasConceptScore W1980095812C2780723820 @default.
- W1980095812 hasConceptScore W1980095812C53645450 @default.
- W1980095812 hasConceptScore W1980095812C57074206 @default.
- W1980095812 hasConceptScore W1980095812C62478195 @default.
- W1980095812 hasConceptScore W1980095812C86803240 @default.
- W1980095812 hasConceptScore W1980095812C95444343 @default.