FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980096031> ?p ?o ?g. }

• W1980096031 endingPage "661" @default.
• W1980096031 startingPage "655" @default.
• W1980096031 abstract "Clinical guidelines for anaphylaxis recommend epinephrine as first-line therapy but do not distinguish between early and late stages of anaphylaxis. The delay between the onset of anaphylaxis and initiation of treatment may influence the choice of the optimal vasoconstrictor (epinephrine versus arginine vasopressin [AVP]). Anesthetized rats were allocated into control and three anaphylaxis groups (n = 6 per group). The aortas were removed at 5 min (control) and at 5, 15, or 30 min during anaphylaxis and were contracted in organ baths by increasing concentrations of epinephrine or AVP. After washout of the initial agonist, each ring was contracted with the alternative drug. Separately, aortic rings removed during early versus late anaphylaxis were contracted by AVP ± pretreatment with N(G)-nitro-l-arginine methyl ester (l-NAME) (10−4 M), a NOS inhibitor. Aortic rings removed during late versus early anaphylaxis were less responsive to epinephrine (EC50 at 5 min, 8.4 nM [4.9 - 11.8]; EC50 at 30 min, 18.2 nM [11.9 - 24.4]; P = 0.04) and AVP (EC50 at 5 min, 8.1 nM [4.9 - 11.3]; EC50 at 30 min, 19.7 nM [10.9 - 28.6]; P = 0.02). Pre-exposure to AVP enhanced the subsequent contractile effect of epinephrine in aortic rings removed during late anaphylaxis (maximal contractile effect, 1.02 g [0.76 - 1.28]) versus early anaphylaxis (maximal contractile effect, 0.44 g [0.28 - 0.59]; P = 0.005). In contrast to early anaphylaxis, pretreatment with l-NAME decreased responsiveness to AVP during late anaphylaxis (EC50, 2.47 nM [1.79 - 3.16], 1.55 nM [1.11 - 1.98] for ± l-NAME, respectively; P = 0.03). During anaphylaxis, the vasoconstrictive effects of AVP or epinephrine were time dependent. Arginine vasopressin might have beneficial effects during late anaphylaxis via mechanisms involving NO." @default.
• W1980096031 created "2016-06-24" @default.
• W1980096031 creator A5012873342 @default.
• W1980096031 creator A5061736448 @default.
• W1980096031 date "2010-06-01" @default.
• W1980096031 modified "2023-10-18" @default.
• W1980096031 title "PRE-EXPOSURE TO VASOPRESSIN POTENTIATES THE VASOCONSTRICTIVE EFFECT OF EPINEPHRINE IN RAT AORTA ISOLATED DURING LATE ANAPHYLAXIS" @default.
• W1980096031 cites W123197124 @default.
• W1980096031 cites W1583056248 @default.
• W1980096031 cites W1749321932 @default.
• W1980096031 cites W1967262943 @default.
• W1980096031 cites W1977131844 @default.
• W1980096031 cites W1978276472 @default.
• W1980096031 cites W1983187255 @default.
• W1980096031 cites W1986564388 @default.
• W1980096031 cites W2016610139 @default.
• W1980096031 cites W2021271906 @default.
• W1980096031 cites W2021997881 @default.
• W1980096031 cites W2022406624 @default.
• W1980096031 cites W2026695464 @default.
• W1980096031 cites W2031525886 @default.
• W1980096031 cites W2042607767 @default.
• W1980096031 cites W2059917926 @default.
• W1980096031 cites W2070491301 @default.
• W1980096031 cites W2080555943 @default.
• W1980096031 cites W2082672002 @default.
• W1980096031 cites W2087133254 @default.
• W1980096031 cites W2092576934 @default.
• W1980096031 cites W2094412782 @default.
• W1980096031 cites W2101449773 @default.
• W1980096031 cites W2119961921 @default.
• W1980096031 cites W2127655000 @default.
• W1980096031 cites W2414245104 @default.
• W1980096031 cites W4236678270 @default.
• W1980096031 doi "https://doi.org/10.1097/shk.0b013e3181cb93d5" @default.
• W1980096031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19940810" @default.
• W1980096031 hasPublicationYear "2010" @default.
• W1980096031 type Work @default.
• W1980096031 sameAs 1980096031 @default.
• W1980096031 citedByCount "3" @default.
• W1980096031 countsByYear W19800960312013 @default.
• W1980096031 crossrefType "journal-article" @default.
• W1980096031 hasAuthorship W1980096031A5012873342 @default.
• W1980096031 hasAuthorship W1980096031A5061736448 @default.
• W1980096031 hasBestOaLocation W19800960311 @default.
• W1980096031 hasConcept C126322002 @default.
• W1980096031 hasConcept C134018914 @default.
• W1980096031 hasConcept C203014093 @default.
• W1980096031 hasConcept C207480886 @default.
• W1980096031 hasConcept C2775859304 @default.
• W1980096031 hasConcept C2775933838 @default.
• W1980096031 hasConcept C2776370428 @default.
• W1980096031 hasConcept C42219234 @default.
• W1980096031 hasConcept C71924100 @default.
• W1980096031 hasConceptScore W1980096031C126322002 @default.
• W1980096031 hasConceptScore W1980096031C134018914 @default.
• W1980096031 hasConceptScore W1980096031C203014093 @default.
• W1980096031 hasConceptScore W1980096031C207480886 @default.
• W1980096031 hasConceptScore W1980096031C2775859304 @default.
• W1980096031 hasConceptScore W1980096031C2775933838 @default.
• W1980096031 hasConceptScore W1980096031C2776370428 @default.
• W1980096031 hasConceptScore W1980096031C42219234 @default.
• W1980096031 hasConceptScore W1980096031C71924100 @default.
• W1980096031 hasIssue "6" @default.
• W1980096031 hasLocation W19800960311 @default.
• W1980096031 hasLocation W19800960312 @default.
• W1980096031 hasLocation W19800960313 @default.
• W1980096031 hasOpenAccess W1980096031 @default.
• W1980096031 hasPrimaryLocation W19800960311 @default.
• W1980096031 hasRelatedWork W1979135499 @default.
• W1980096031 hasRelatedWork W1996925165 @default.
• W1980096031 hasRelatedWork W2001204924 @default.
• W1980096031 hasRelatedWork W2044395968 @default.
• W1980096031 hasRelatedWork W2062252989 @default.
• W1980096031 hasRelatedWork W2064770851 @default.
• W1980096031 hasRelatedWork W2140886962 @default.
• W1980096031 hasRelatedWork W2146779265 @default.
• W1980096031 hasRelatedWork W2396646349 @default.
• W1980096031 hasRelatedWork W2127017265 @default.
• W1980096031 hasVolume "33" @default.
• W1980096031 isParatext "false" @default.
• W1980096031 isRetracted "false" @default.
• W1980096031 magId "1980096031" @default.
• W1980096031 workType "article" @default.