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- W1980098678 abstract "Sir, We report a 63‐year‐old woman who had clinical, histological and immunopathological features of pemphigus vulgaris, and the novel feature of circulating antibodies to desmoplakin (DP) I and DP II. A 63‐year‐old woman was seen in March 1998 with a 2‐month history of flaccid bullae on the scalp and trunk and an oral mucosal erosion. On examination, several slightly erythematous, variably sized flaccid bullae were observed on the scalp, trunk and oral mucosa. Ophthalmological examination showed mild bilateral corneal erosions. Routine laboratory tests showed no abnormalities except for elevated aspartate aminotransferase (118 U L−1) and alanine aminotransferase (122 U L−1). Autoantibody testing showed positive antinuclear antibodies (ANA; 1 : 640, with homogeneous pattern), rheumatoid factor, antimitochondrial and antigastric parietal cell antibodies. Abdominal ultrasound showed diffuse liver disease, but other radiological findings were not significant. Based on the serological and radiological findings, autoimmune hepatitis was diagnosed. A skin biopsy showed a suprabasal acantholytic blister characteristic of pemphigus vulgaris. Direct immunofluorescence of a skin biopsy specimen showed deposition of IgG on keratinocyte cell surfaces. Indirect immunofluorescence performed in March 1998 showed IgG deposition on the keratinocyte cell surfaces at a titre of 1 : 1280." @default.
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- W1980098678 date "2001-11-01" @default.
- W1980098678 modified "2023-09-28" @default.
- W1980098678 title "Pemphigus vulgaris with autoantibodies to desmoplakin." @default.
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- W1980098678 doi "https://doi.org/10.1046/j.1365-2133.2001.04415.x" @default.
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