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• W1980114643 abstract "1 Adenosine 5′ triphosphate (ATP) (0.5–500 μ M ) or muscarine (0.1–1.0 μ M ) suppressed M‐current/conductance ( I M / g M ) in B‐cells of bullfrog sympathetic ganglion. Both agonists suppressed steady‐state M‐conductance ( g M ) at –30 mV and there was either no change or a slight increase in the time constants for g M activation (τ a at –30 mV) and deactivation (τ d at –50 mV). 2 It has previously been shown that experimental elevation of intracellular Ca 2+ concentration ([Ca 2+ ] i ) suppresses g M and this is associated with decreases in both τ a and τ d . As these changes in kinetics differ from those we observe with agonist application, our results cast doubt on the hypothesis that elevation of [Ca 2+ ] i is involved in the transduction mechanism for ATP‐ or muscarine‐induced g M suppression." @default.
• W1980114643 created "2016-06-24" @default.
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• W1980114643 date "2001-02-10" @default.
• W1980114643 modified "2023-10-18" @default.
• W1980114643 title "Modulation of M-channel conductance by adenosine 5' triphosphate in bullfrog sympathetic B-neurones" @default.
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• W1980114643 doi "https://doi.org/10.1046/j.1365-2680.2001.00208.x" @default.
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