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- W1980124892 abstract "Researchers assessed the effectiveness of prazosin combined with scorpion antivenom in assisting recovery from scorpion sting. An open label randomised controlled trial study design was used. The control treatment was prazosin alone. The setting was a hospital and research centre in Mahad, a region of India. Participants were patients with grade 2 scorpion envenomation, older than 6 months, and with no cardiorespiratory or central nervous system abnormalities. In total, 70 patients were recruited and allocated to treatment (35 to prazosin and scorpion antivenom, and 35 to prazosin alone) by block randomisation.1 The primary endpoint was resolution of the clinical syndrome within 10 hours of treatment, as assessed by the researchers. The secondary endpoints included the time needed for complete resolution of the clinical syndrome. The proportion of patients who showed complete resolution of the clinical syndrome within 10 hours of treatment was significantly greater in the prazosin plus antivenom group than in the prazosin alone group (91.4% v 22.9%; difference 68.5%, 95% confidence interval 51.8% to 85.2%; P<0.001). The mean time needed for complete resolution of the clinical syndrome was significantly shorter in the antivenom plus prazosin group (8 v 17.7 h; difference −9.7 h, −6.9 to −12.4); P<0.001). The researchers concluded that recovery from a scorpion sting was hastened by simultaneous administration of scorpion antivenom plus prazosin compared with prazosin alone. Which of the following statements, if any, are true?" @default.
- W1980124892 created "2016-06-24" @default.
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- W1980124892 date "2014-05-23" @default.
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- W1980124892 title "What is an open label trial?" @default.
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- W1980124892 doi "https://doi.org/10.1136/bmj.g3434" @default.
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