FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980130462> ?p ?o ?g. }

• W1980130462 endingPage "e22879" @default.
• W1980130462 startingPage "e22879" @default.
• W1980130462 abstract "Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specific amino acids required for partner binding, CDK activation and subcellular localization. We find that CDK1, CDK2, p21, p27 and p107 have overlapping but distinct requirements for association with this protein. Our data highlight the crucial importance of the N-terminal α helix, in conjunction with the α3 helix within the cyclin box, in activating CDK. Several Cyclin A2 mutants selectively bind to either CDK1 or CDK2. We demonstrate that association of Cyclin A2 to proteins such as CDK2 that was previously suggested as crucial is not a prerequisite for its nuclear localization, and we propose that the whole protein structure is involved." @default.
• W1980130462 created "2016-06-24" @default.
• W1980130462 creator A5022840701 @default.
• W1980130462 creator A5037880913 @default.
• W1980130462 creator A5043102715 @default.
• W1980130462 creator A5053005464 @default.
• W1980130462 date "2011-07-28" @default.
• W1980130462 modified "2023-09-26" @default.
• W1980130462 title "Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements" @default.
• W1980130462 cites W1502721583 @default.
• W1980130462 cites W1552046925 @default.
• W1980130462 cites W1961241993 @default.
• W1980130462 cites W1968478878 @default.
• W1980130462 cites W1969939692 @default.
• W1980130462 cites W2001391993 @default.
• W1980130462 cites W2013680732 @default.
• W1980130462 cites W2018537155 @default.
• W1980130462 cites W2034310924 @default.
• W1980130462 cites W2039543791 @default.
• W1980130462 cites W2041624029 @default.
• W1980130462 cites W2085532055 @default.
• W1980130462 cites W2089648262 @default.
• W1980130462 cites W2097366729 @default.
• W1980130462 cites W2129381867 @default.
• W1980130462 cites W2135236253 @default.
• W1980130462 cites W2146234147 @default.
• W1980130462 cites W2150994597 @default.
• W1980130462 cites W2155956189 @default.
• W1980130462 cites W2159610869 @default.
• W1980130462 cites W2166683405 @default.
• W1980130462 cites W2169927110 @default.
• W1980130462 doi "https://doi.org/10.1371/journal.pone.0022879" @default.
• W1980130462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3145769" @default.
• W1980130462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21829545" @default.
• W1980130462 hasPublicationYear "2011" @default.
• W1980130462 type Work @default.
• W1980130462 sameAs 1980130462 @default.
• W1980130462 citedByCount "50" @default.
• W1980130462 countsByYear W19801304622012 @default.
• W1980130462 countsByYear W19801304622013 @default.
• W1980130462 countsByYear W19801304622014 @default.
• W1980130462 countsByYear W19801304622015 @default.
• W1980130462 countsByYear W19801304622016 @default.
• W1980130462 countsByYear W19801304622017 @default.
• W1980130462 countsByYear W19801304622018 @default.
• W1980130462 countsByYear W19801304622019 @default.
• W1980130462 countsByYear W19801304622020 @default.
• W1980130462 countsByYear W19801304622021 @default.
• W1980130462 countsByYear W19801304622022 @default.
• W1980130462 countsByYear W19801304622023 @default.
• W1980130462 crossrefType "journal-article" @default.
• W1980130462 hasAuthorship W1980130462A5022840701 @default.
• W1980130462 hasAuthorship W1980130462A5037880913 @default.
• W1980130462 hasAuthorship W1980130462A5043102715 @default.
• W1980130462 hasAuthorship W1980130462A5053005464 @default.
• W1980130462 hasBestOaLocation W19801304621 @default.
• W1980130462 hasConcept C11882975 @default.
• W1980130462 hasConcept C120089663 @default.
• W1980130462 hasConcept C120504264 @default.
• W1980130462 hasConcept C124320809 @default.
• W1980130462 hasConcept C1491633281 @default.
• W1980130462 hasConcept C16438837 @default.
• W1980130462 hasConcept C175738201 @default.
• W1980130462 hasConcept C184235292 @default.
• W1980130462 hasConcept C28179978 @default.
• W1980130462 hasConcept C29537977 @default.
• W1980130462 hasConcept C55493867 @default.
• W1980130462 hasConcept C82495950 @default.
• W1980130462 hasConcept C86803240 @default.
• W1980130462 hasConcept C95444343 @default.
• W1980130462 hasConcept C97029542 @default.
• W1980130462 hasConcept C9743823 @default.
• W1980130462 hasConceptScore W1980130462C11882975 @default.
• W1980130462 hasConceptScore W1980130462C120089663 @default.
• W1980130462 hasConceptScore W1980130462C120504264 @default.
• W1980130462 hasConceptScore W1980130462C124320809 @default.
• W1980130462 hasConceptScore W1980130462C1491633281 @default.
• W1980130462 hasConceptScore W1980130462C16438837 @default.
• W1980130462 hasConceptScore W1980130462C175738201 @default.
• W1980130462 hasConceptScore W1980130462C184235292 @default.
• W1980130462 hasConceptScore W1980130462C28179978 @default.
• W1980130462 hasConceptScore W1980130462C29537977 @default.
• W1980130462 hasConceptScore W1980130462C55493867 @default.
• W1980130462 hasConceptScore W1980130462C82495950 @default.
• W1980130462 hasConceptScore W1980130462C86803240 @default.
• W1980130462 hasConceptScore W1980130462C95444343 @default.
• W1980130462 hasConceptScore W1980130462C97029542 @default.
• W1980130462 hasConceptScore W1980130462C9743823 @default.
• W1980130462 hasIssue "7" @default.
• W1980130462 hasLocation W19801304621 @default.
• W1980130462 hasLocation W19801304622 @default.
• W1980130462 hasLocation W19801304623 @default.
• W1980130462 hasLocation W19801304624 @default.
• W1980130462 hasLocation W19801304625 @default.
• W1980130462 hasLocation W19801304626 @default.
• W1980130462 hasOpenAccess W1980130462 @default.
• W1980130462 hasPrimaryLocation W19801304621 @default.
• W1980130462 hasRelatedWork W1533932386 @default.

• next