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• W1980144092 abstract "At present there is no safe and effective vaccine for respiratory syncytial virus (RSV). DNA vaccines encoding RSV surface glycoproteins are one option being examined. Current methods to deliver DNA vaccines generally require repeated high dose intramuscular or intradermal administration for effectiveness. In this study, we examine the efficacy of pulmonary DNA vaccination using low dose DNA vaccines encoding the RSV F glycoprotein conjugated to macroaggregated albumin (MAA-F). Single vaccination of BALB/c mice with 1 μg MAA-F was ineffective, however mice boosted with an additional 1 μg MAA-F, or vaccinated a single time with 10 μg MAA-F, developed substantially improved immunity associated with reduced viral titers, increased anti-F antibody responses, and enhanced Th1 and Th2 intracellular cytokine responses. This study shows that MAA may be a useful carrier for RSV DNA vaccines." @default.
• W1980144092 created "2016-06-24" @default.
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• W1980144092 date "2004-06-01" @default.
• W1980144092 modified "2023-10-17" @default.
• W1980144092 title "Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particles" @default.
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• W1980144092 doi "https://doi.org/10.1016/j.vaccine.2003.11.050" @default.
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• W1980144092 hasPublicationYear "2004" @default.
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