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• W1980149061 endingPage "1036" @default.
• W1980149061 startingPage "1032" @default.
• W1980149061 abstract "In this study, luteolin-7-O-glucoside (L7G), an herbal medicine isolated from Ailanthus altissima, inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C4 (LTC4) production in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner with an IC50 of 3.0 μM. To determine the action mechanism of L7G, we performed immunoblotting for cytosolic phospholipase A2 (cPLA2) and mitogen-activated protein kinases (MAPKs) following c-kit ligand (KL)-induced activation of BMMCs with or without L7G. Inhibition of LTC4 production by L7G was accompanied by a decrease in cPLA2 phosphorylation, which occurred via the extracellular signal-regulated protein kinase-1/2 (ERK1/2) and p38 and c-Jun N-terminal kinase (JNK) pathways. In addition, L7G also attenuated mast cell degranulation in a dose-dependent manner (IC50, 22.8 μM) through inhibition of phospholipase Cγ1 (PLCγ1) phosphorylation. Our results suggest that the anti-asthmatic activity of L7G may be mediated in part via the inhibition of LTC4 generation and mast cell degranulation." @default.
• W1980149061 created "2016-06-24" @default.
• W1980149061 creator A5006366017 @default.
• W1980149061 creator A5041813924 @default.
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• W1980149061 date "2011-01-01" @default.
• W1980149061 modified "2023-10-13" @default.
• W1980149061 title "Luteolin-7-O-glucoside Suppresses Leukotriene C4 Production and Degranulation by Inhibiting the Phosphorylation of Mitogen Activated Protein Kinases and Phospholipase C.GAMMA.1 in Activated Mouse Bone Marrow-Derived Mast Cells" @default.
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• W1980149061 doi "https://doi.org/10.1248/bpb.34.1032" @default.
• W1980149061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21720009" @default.
• W1980149061 hasPublicationYear "2011" @default.
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