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• W1980151308 abstract "Tendinopathy, although common, is difficult to treat, and most currently available treatments are not effective or evidence-based. As outlined in this Review, the molecular pathology of the tendon is being elucidated and could lead to the identification of novel therapeutic agents for the treatment of chronic tendinopathies. Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins. The tendon matrix is maintained by the resident tenocytes, and there is evidence of a continuous process of matrix remodeling, although the rate of turnover varies at different sites. A change in remodeling activity is associated with the onset of tendinopathy. Major molecular changes include increased expression of type III collagen, fibronectin, tenascin C, aggrecan and biglycan. These changes are consistent with repair, but they might also be an adaptive response to changes in mechanical loading. Repeated minor strain is thought to be the major precipitating factor in tendinopathy, although further work is required to determine whether it is mechanical overstimulation or understimulation that leads to the change in tenocyte activity. Metalloproteinase enzymes have an important role in the tendon matrix, being responsible for the degradation of collagen and proteoglycan in both healthy patients and those with disease. Metalloproteinases that show increased expression in painful tendinopathy include ADAM (a disintegrin and metalloproteinase)-12 and MMP (matrix metalloproteinase)-23. The role of these enzymes in tendon pathology is unknown, and further work is required to identify novel and specific molecular targets for therapy." @default.
• W1980151308 created "2016-06-24" @default.
• W1980151308 creator A5077417480 @default.
• W1980151308 date "2008-02-01" @default.
• W1980151308 modified "2023-10-18" @default.
• W1980151308 title "Tendinopathy—from basic science to treatment" @default.
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• W1980151308 doi "https://doi.org/10.1038/ncprheum0700" @default.
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