FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980158514> ?p ?o ?g. }

• W1980158514 endingPage "721" @default.
• W1980158514 startingPage "709" @default.
• W1980158514 abstract "The application of molecular techniques to characterize clinical kidney biopsies has the potential to provide insights into glomerular diseases that cannot be revealed by traditional renal pathology. The present work is a proof-of-concept approach to test whether proteomic analysis of glomeruli isolated from clinical biopsies by laser capture microdissection can provide unique information regarding differentially expressed proteins relevant to disease pathogenesis. The proteomes of glomeruli isolated by laser capture microdissection from biopsies of normal kidneys (living-related donor kidneys) were compared with those from patients with diabetic nephropathy, lupus nephritis, and fibronectin glomerulopathy. Glomerular proteins were extracted, trypsin digested, and subjected to liquid chromatography–tandem mass spectrometry for identification and quantitation. Relative to normal glomeruli, all disease-associated glomeruli showed an increased presence of complement components, a marked decline in podocyte-associated proteins, and a decrease in proteins associated with cellular metabolism. Additionally, fibronectin glomerulopathy glomeruli differed from all the other glomeruli because of a significant accumulation of fibronectin and fibulin. This study demonstrates that our method acquires reproducible and quantitative proteomic information from laser capture microdissection isolates that can be used to characterize the molecular features of glomerular diseases." @default.
• W1980158514 created "2016-06-24" @default.
• W1980158514 creator A5009451090 @default.
• W1980158514 creator A5009841017 @default.
• W1980158514 creator A5010304127 @default.
• W1980158514 creator A5020748197 @default.
• W1980158514 creator A5033500089 @default.
• W1980158514 creator A5041708436 @default.
• W1980158514 creator A5042356850 @default.
• W1980158514 creator A5044705669 @default.
• W1980158514 creator A5064913957 @default.
• W1980158514 creator A5069212517 @default.
• W1980158514 creator A5077634371 @default.
• W1980158514 date "2012-05-01" @default.
• W1980158514 modified "2023-10-18" @default.
• W1980158514 title "Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli" @default.
• W1980158514 cites W1486108017 @default.
• W1980158514 cites W1527449289 @default.
• W1980158514 cites W1537759294 @default.
• W1980158514 cites W1950988583 @default.
• W1980158514 cites W1970005702 @default.
• W1980158514 cites W1975001209 @default.
• W1980158514 cites W1978282603 @default.
• W1980158514 cites W1987922761 @default.
• W1980158514 cites W1987933521 @default.
• W1980158514 cites W1990273811 @default.
• W1980158514 cites W1991700466 @default.
• W1980158514 cites W1997504014 @default.
• W1980158514 cites W2001243726 @default.
• W1980158514 cites W2014130516 @default.
• W1980158514 cites W2018215777 @default.
• W1980158514 cites W2022492763 @default.
• W1980158514 cites W2022773091 @default.
• W1980158514 cites W2022787091 @default.
• W1980158514 cites W2025858264 @default.
• W1980158514 cites W2027231714 @default.
• W1980158514 cites W2029236961 @default.
• W1980158514 cites W2034514722 @default.
• W1980158514 cites W2037031112 @default.
• W1980158514 cites W2041932634 @default.
• W1980158514 cites W2045997268 @default.
• W1980158514 cites W2058081546 @default.
• W1980158514 cites W2061519721 @default.
• W1980158514 cites W2063543381 @default.
• W1980158514 cites W2066586115 @default.
• W1980158514 cites W2068308495 @default.
• W1980158514 cites W2077089592 @default.
• W1980158514 cites W2080418501 @default.
• W1980158514 cites W2086772749 @default.
• W1980158514 cites W2091502101 @default.
• W1980158514 cites W2091718490 @default.
• W1980158514 cites W2097885715 @default.
• W1980158514 cites W2101950619 @default.
• W1980158514 cites W2108304538 @default.
• W1980158514 cites W2125680409 @default.
• W1980158514 cites W2128084207 @default.
• W1980158514 cites W2134611932 @default.
• W1980158514 cites W2138846715 @default.
• W1980158514 cites W2142421383 @default.
• W1980158514 cites W2146152479 @default.
• W1980158514 cites W2146390971 @default.
• W1980158514 cites W2149068009 @default.
• W1980158514 cites W2167728354 @default.
• W1980158514 cites W224510830 @default.
• W1980158514 cites W2339597902 @default.
• W1980158514 cites W2411285281 @default.
• W1980158514 cites W2417158027 @default.
• W1980158514 cites W4234713026 @default.
• W1980158514 doi "https://doi.org/10.1038/modpathol.2011.205" @default.
• W1980158514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432020" @default.
• W1980158514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22282304" @default.
• W1980158514 hasPublicationYear "2012" @default.
• W1980158514 type Work @default.
• W1980158514 sameAs 1980158514 @default.
• W1980158514 citedByCount "53" @default.
• W1980158514 countsByYear W19801585142012 @default.
• W1980158514 countsByYear W19801585142013 @default.
• W1980158514 countsByYear W19801585142014 @default.
• W1980158514 countsByYear W19801585142015 @default.
• W1980158514 countsByYear W19801585142016 @default.
• W1980158514 countsByYear W19801585142017 @default.
• W1980158514 countsByYear W19801585142018 @default.
• W1980158514 countsByYear W19801585142019 @default.
• W1980158514 countsByYear W19801585142020 @default.
• W1980158514 countsByYear W19801585142021 @default.
• W1980158514 countsByYear W19801585142022 @default.
• W1980158514 countsByYear W19801585142023 @default.
• W1980158514 crossrefType "journal-article" @default.
• W1980158514 hasAuthorship W1980158514A5009451090 @default.
• W1980158514 hasAuthorship W1980158514A5009841017 @default.
• W1980158514 hasAuthorship W1980158514A5010304127 @default.
• W1980158514 hasAuthorship W1980158514A5020748197 @default.
• W1980158514 hasAuthorship W1980158514A5033500089 @default.
• W1980158514 hasAuthorship W1980158514A5041708436 @default.
• W1980158514 hasAuthorship W1980158514A5042356850 @default.
• W1980158514 hasAuthorship W1980158514A5044705669 @default.
• W1980158514 hasAuthorship W1980158514A5064913957 @default.
• W1980158514 hasAuthorship W1980158514A5069212517 @default.

• next