Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980162007> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1980162007 endingPage "13077" @default.
- W1980162007 startingPage "13072" @default.
- W1980162007 abstract "The specific-locus test (SLT) detects new mutants among mice heterozygous for seven recessive visible markers. Spontaneous mutations can be manifested not only as singleton whole-body mutants in controls (for which we report new data), but as mosaics-either visible (manifesting mottled coat color) in the scored generation (G2) or masked, among the wild-type parental generation (G1). Masked G1 mosaics reveal themselves by producing clusters of whole-body mutants in G2. We provide evidence that most, if not all, mosaics detected in the SLT (both radiation and control progenies) result from a single-strand spontaneous mutation subsequent to the last premeiotic mitosis and before the first postmeiotic one of a parental genome-the perigametic interval. Such events in the genomes of the G1 and Gzero results, respectively, in visible and masked 50:50 mosaics. Per cell cycle, the spontaneous mutation rate in the perigametic interval is much higher than that in pregamete mitotic divisions. A clearly different locus spectrum further supports the hypothesis of different origin, and casts further doubt on the validity of the doubling-dose risk-estimation method. Because mosaics cannot have arisen in mitotic germ cells, and are not induced by radiation exposure in the perigametic interval, they should not be included in calculations of radiation-induced germ-line mutation rates. For per-generation calculations, inclusion of mosaics yields a spontaneous frequency 1.7 times that calculated from singletons alone for mutations contributed by males; including both sexes, the multiple is 2.2." @default.
- W1980162007 created "2016-06-24" @default.
- W1980162007 creator A5004007494 @default.
- W1980162007 creator A5025628176 @default.
- W1980162007 date "1996-11-12" @default.
- W1980162007 modified "2023-10-18" @default.
- W1980162007 title "Spontaneous mutations recovered as mosaics in the mouse specific-locus test" @default.
- W1980162007 cites W1835674844 @default.
- W1980162007 cites W1935685461 @default.
- W1980162007 cites W1984465569 @default.
- W1980162007 cites W1985632898 @default.
- W1980162007 cites W2011144168 @default.
- W1980162007 cites W2012648980 @default.
- W1980162007 cites W2014617952 @default.
- W1980162007 cites W2021682571 @default.
- W1980162007 cites W2034562887 @default.
- W1980162007 cites W2039495461 @default.
- W1980162007 cites W2044611127 @default.
- W1980162007 cites W2057941157 @default.
- W1980162007 cites W2058073629 @default.
- W1980162007 cites W2062603185 @default.
- W1980162007 cites W2065682755 @default.
- W1980162007 cites W2078418979 @default.
- W1980162007 cites W2102784867 @default.
- W1980162007 cites W2105629018 @default.
- W1980162007 cites W2115183810 @default.
- W1980162007 cites W2123734454 @default.
- W1980162007 cites W2170460714 @default.
- W1980162007 cites W2506800683 @default.
- W1980162007 cites W64558359 @default.
- W1980162007 cites W937447790 @default.
- W1980162007 doi "https://doi.org/10.1073/pnas.93.23.13072" @default.
- W1980162007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24048" @default.
- W1980162007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8917546" @default.
- W1980162007 hasPublicationYear "1996" @default.
- W1980162007 type Work @default.
- W1980162007 sameAs 1980162007 @default.
- W1980162007 citedByCount "99" @default.
- W1980162007 countsByYear W19801620072012 @default.
- W1980162007 countsByYear W19801620072013 @default.
- W1980162007 countsByYear W19801620072014 @default.
- W1980162007 countsByYear W19801620072015 @default.
- W1980162007 countsByYear W19801620072016 @default.
- W1980162007 countsByYear W19801620072017 @default.
- W1980162007 countsByYear W19801620072018 @default.
- W1980162007 countsByYear W19801620072019 @default.
- W1980162007 countsByYear W19801620072020 @default.
- W1980162007 countsByYear W19801620072021 @default.
- W1980162007 countsByYear W19801620072022 @default.
- W1980162007 countsByYear W19801620072023 @default.
- W1980162007 crossrefType "journal-article" @default.
- W1980162007 hasAuthorship W1980162007A5004007494 @default.
- W1980162007 hasAuthorship W1980162007A5025628176 @default.
- W1980162007 hasBestOaLocation W19801620071 @default.
- W1980162007 hasConcept C102306862 @default.
- W1980162007 hasConcept C104317684 @default.
- W1980162007 hasConcept C127764415 @default.
- W1980162007 hasConcept C143065580 @default.
- W1980162007 hasConcept C153911025 @default.
- W1980162007 hasConcept C54355233 @default.
- W1980162007 hasConcept C84597430 @default.
- W1980162007 hasConcept C86803240 @default.
- W1980162007 hasConcept C93304396 @default.
- W1980162007 hasConcept C98638677 @default.
- W1980162007 hasConceptScore W1980162007C102306862 @default.
- W1980162007 hasConceptScore W1980162007C104317684 @default.
- W1980162007 hasConceptScore W1980162007C127764415 @default.
- W1980162007 hasConceptScore W1980162007C143065580 @default.
- W1980162007 hasConceptScore W1980162007C153911025 @default.
- W1980162007 hasConceptScore W1980162007C54355233 @default.
- W1980162007 hasConceptScore W1980162007C84597430 @default.
- W1980162007 hasConceptScore W1980162007C86803240 @default.
- W1980162007 hasConceptScore W1980162007C93304396 @default.
- W1980162007 hasConceptScore W1980162007C98638677 @default.
- W1980162007 hasIssue "23" @default.
- W1980162007 hasLocation W19801620071 @default.
- W1980162007 hasLocation W19801620072 @default.
- W1980162007 hasLocation W19801620073 @default.
- W1980162007 hasLocation W19801620074 @default.
- W1980162007 hasOpenAccess W1980162007 @default.
- W1980162007 hasPrimaryLocation W19801620071 @default.
- W1980162007 hasRelatedWork W1507023994 @default.
- W1980162007 hasRelatedWork W1783066005 @default.
- W1980162007 hasRelatedWork W1976650656 @default.
- W1980162007 hasRelatedWork W2051621914 @default.
- W1980162007 hasRelatedWork W2057739827 @default.
- W1980162007 hasRelatedWork W2066266121 @default.
- W1980162007 hasRelatedWork W2132042562 @default.
- W1980162007 hasRelatedWork W2148375889 @default.
- W1980162007 hasRelatedWork W2148485332 @default.
- W1980162007 hasRelatedWork W2136219099 @default.
- W1980162007 hasVolume "93" @default.
- W1980162007 isParatext "false" @default.
- W1980162007 isRetracted "false" @default.
- W1980162007 magId "1980162007" @default.
- W1980162007 workType "article" @default.