FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980164069> ?p ?o ?g. }

• W1980164069 endingPage "S59" @default.
• W1980164069 startingPage "S53" @default.
• W1980164069 abstract "The cellular and molecular mechanisms of insulin secretion are being intensively investigated, yet most researchers are seemingly unaware of the complexity of the dynamic regulation of the secretion. In this article, we summarize studies of the physiology of insulin secretion performed over several decades. The insulin response of perifused islets of rats, perfused rat pancreas, or that of a human, to a square-wave glucose stimulus is biphasic, a transient first-phase response of 4- to 10-min duration followed by a gradual rise in secretion rates (second-phase response). Several hypotheses have been proposed to account for the phasic nature of insulin secretion; they are briefly discussed in this review. We have favored the hypothesis that nutrient stimulators such as glucose, in addition to a primary and almost immediate secretory signal, with time induce both stimulatory and inhibitory messages in the β-cell, and those messages modulate the primary insulinogenic signal. Indeed, studies in the rat pancreas and in humans have demonstrated that short stimulations with glucose generate a state of refractoriness of the insulin secretion, which we have termed time-dependent inhibition (TDI). Nonnutrient secretagogues such as arginine induce strong TDI independent of the duration of stimulation. Once the agent is removed, TDI persists for a considerable period. In contrast, prolonged stimulations with glucose (and other nutrients) lead to the amplification of the insulin response to subsequent stimuli; this can be demonstrated in the perfused rat pancreas, in perifused islets from several rodents, and in humans. We have termed this stimulatory signal time-dependent potentiation (TDP). The generation of TDP requires higher glucose concentrations and prolonged stimulation; the effect is retained for some time after cessation of the stimulus. Of major interest is the observation that, while the acute insulin response to glucose is severely reduced in glucose-intolerant animals and humans, TDP seems to be intact. The cellular mechanisms of TDI and TDP are poorly understood, but data reviewed here suggest that they are distinct from those that lead to the acute insulin response to stimuli. A model is proposed whereby the magnitude and kinetics of the insulin response to a given stimulus reflect the balance between TDP and TDI. Researchers studying the cellular and molecular mechanisms of insulin release are urged to take into consideration these complex and opposing factors which regulate insulin secretion." @default.
• W1980164069 created "2016-06-24" @default.
• W1980164069 creator A5076271317 @default.
• W1980164069 creator A5076897853 @default.
• W1980164069 date "2002-02-01" @default.
• W1980164069 modified "2023-10-14" @default.
• W1980164069 title "Modeling Phasic Insulin Release" @default.
• W1980164069 cites W1918502072 @default.
• W1980164069 cites W1931693263 @default.
• W1980164069 cites W1963953521 @default.
• W1980164069 cites W1974554536 @default.
• W1980164069 cites W1990024356 @default.
• W1980164069 cites W2003857284 @default.
• W1980164069 cites W2004593611 @default.
• W1980164069 cites W2020505374 @default.
• W1980164069 cites W2023387721 @default.
• W1980164069 cites W2032306517 @default.
• W1980164069 cites W2043162493 @default.
• W1980164069 cites W2046594571 @default.
• W1980164069 cites W2063804778 @default.
• W1980164069 cites W2068803404 @default.
• W1980164069 cites W2069398576 @default.
• W1980164069 cites W2083454642 @default.
• W1980164069 cites W2106586196 @default.
• W1980164069 cites W2117647378 @default.
• W1980164069 cites W2120711739 @default.
• W1980164069 cites W2133217243 @default.
• W1980164069 cites W2134485672 @default.
• W1980164069 cites W2135231724 @default.
• W1980164069 cites W2140951430 @default.
• W1980164069 cites W2142452255 @default.
• W1980164069 cites W2151479167 @default.
• W1980164069 cites W2155148036 @default.
• W1980164069 cites W2155175015 @default.
• W1980164069 cites W2157337717 @default.
• W1980164069 cites W2164128040 @default.
• W1980164069 cites W2209019241 @default.
• W1980164069 cites W2218148748 @default.
• W1980164069 cites W4234336682 @default.
• W1980164069 cites W4244503335 @default.
• W1980164069 cites W4245584534 @default.
• W1980164069 cites W4249081905 @default.
• W1980164069 cites W4302614031 @default.
• W1980164069 doi "https://doi.org/10.2337/diabetes.51.2007.s53" @default.
• W1980164069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11815459" @default.
• W1980164069 hasPublicationYear "2002" @default.
• W1980164069 type Work @default.
• W1980164069 sameAs 1980164069 @default.
• W1980164069 citedByCount "158" @default.
• W1980164069 countsByYear W19801640692012 @default.
• W1980164069 countsByYear W19801640692013 @default.
• W1980164069 countsByYear W19801640692014 @default.
• W1980164069 countsByYear W19801640692015 @default.
• W1980164069 countsByYear W19801640692016 @default.
• W1980164069 countsByYear W19801640692017 @default.
• W1980164069 countsByYear W19801640692018 @default.
• W1980164069 countsByYear W19801640692019 @default.
• W1980164069 countsByYear W19801640692020 @default.
• W1980164069 countsByYear W19801640692021 @default.
• W1980164069 countsByYear W19801640692022 @default.
• W1980164069 countsByYear W19801640692023 @default.
• W1980164069 crossrefType "journal-article" @default.
• W1980164069 hasAuthorship W1980164069A5076271317 @default.
• W1980164069 hasAuthorship W1980164069A5076897853 @default.
• W1980164069 hasBestOaLocation W19801640691 @default.
• W1980164069 hasConcept C126322002 @default.
• W1980164069 hasConcept C134018914 @default.
• W1980164069 hasConcept C144855686 @default.
• W1980164069 hasConcept C15744967 @default.
• W1980164069 hasConcept C165220095 @default.
• W1980164069 hasConcept C170493617 @default.
• W1980164069 hasConcept C24998067 @default.
• W1980164069 hasConcept C25274449 @default.
• W1980164069 hasConcept C2778764654 @default.
• W1980164069 hasConcept C2779306644 @default.
• W1980164069 hasConcept C2779918689 @default.
• W1980164069 hasConcept C49039625 @default.
• W1980164069 hasConcept C542102704 @default.
• W1980164069 hasConcept C71924100 @default.
• W1980164069 hasConcept C86803240 @default.
• W1980164069 hasConceptScore W1980164069C126322002 @default.
• W1980164069 hasConceptScore W1980164069C134018914 @default.
• W1980164069 hasConceptScore W1980164069C144855686 @default.
• W1980164069 hasConceptScore W1980164069C15744967 @default.
• W1980164069 hasConceptScore W1980164069C165220095 @default.
• W1980164069 hasConceptScore W1980164069C170493617 @default.
• W1980164069 hasConceptScore W1980164069C24998067 @default.
• W1980164069 hasConceptScore W1980164069C25274449 @default.
• W1980164069 hasConceptScore W1980164069C2778764654 @default.
• W1980164069 hasConceptScore W1980164069C2779306644 @default.
• W1980164069 hasConceptScore W1980164069C2779918689 @default.
• W1980164069 hasConceptScore W1980164069C49039625 @default.
• W1980164069 hasConceptScore W1980164069C542102704 @default.
• W1980164069 hasConceptScore W1980164069C71924100 @default.
• W1980164069 hasConceptScore W1980164069C86803240 @default.
• W1980164069 hasIssue "suppl_1" @default.
• W1980164069 hasLocation W19801640691 @default.
• W1980164069 hasLocation W19801640692 @default.

• next