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• W1980191435 abstract "In this work, we hypothesize that a surface modified with both polyethylene glycol (PEG) and hirudin may provide a non-fouling, thrombin-neutralizing surface suitable for blood contacting applications. With gold as a model substrate we used two different approaches to the preparation of such a surface: (1) a “direct” method in which PEG was conjugated to hirudin and the conjugate was then immobilized on the gold; (2) a “sequential” method in which PEG was immobilized on the gold and hirudin then attached to the immobilized PEG. The surfaces were characterized by water contact angle, ellipsometry and XPS. The biological properties were investigated by measuring protein adsorption (fibrinogen and thrombin) from buffer and plasma; thrombin inhibition was measured using a chromogenic substrate assay. Hirudin immobilization was found to be more efficient on surfaces prepared by the “direct” method. “Sequential” surfaces, however, despite having a lower density of hirudin, showed greater biological activity (thrombin binding and inhibition)." @default.
• W1980191435 created "2016-06-24" @default.
• W1980191435 creator A5021774786 @default.
• W1980191435 creator A5036173839 @default.
• W1980191435 creator A5038345120 @default.
• W1980191435 date "2010-12-01" @default.
• W1980191435 modified "2023-10-11" @default.
• W1980191435 title "Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact" @default.
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• W1980191435 doi "https://doi.org/10.1016/j.colsurfb.2010.07.024" @default.
• W1980191435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20709502" @default.
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