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- W1980203670 abstract "Abstract In tissues of starved rats cyclic adenosine 3',5'-monophosphate (cyclic AMP) was determined by an enzymatic isotope dilution method. A single per os application of 1 m-mole/kg β-pyridylcarbinol (or nicotinic acid) caused a bi-phasic change of cyclic AMP simultaneously in epididymal fat, liver and brain: initially a transient decrease of about 20–40 per cent occurred for 30 min followed by an increase of up to 150 per cent of controls after 1 hr. The levels returned to normal after 1hr in liver and brain and after 5 hr in adipose tissue. The increase of cyclic AMP was not related to an increased activity of adenylcyclase in liver homogenate. Cyclic AMP decreased simultaneously with the free fatty acids (FFA) in plasma, but the subsequent increase of cyclic AMP did not parallel any further change in blood plasma, such as an increase of FFA (rebound) and of urea or decrease of cholesterol and triglycerides. It is therefore unlikely that the known changes of plasma metabolites due to β-pyridylcarbinol or nicotinic acid depend directly on variations of total cyclic AMP in the tissues studied." @default.
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- W1980203670 date "1971-01-01" @default.
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- W1980203670 title "Cyclic adenosine 3',5'-monophosphate and adenylcyclase in liver, adipose tissue and brain of rats treated with β-pyridylcarbinol" @default.
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- W1980203670 doi "https://doi.org/10.1016/0006-2952(71)90467-9" @default.
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