FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980214977> ?p ?o ?g. }

• W1980214977 endingPage "286" @default.
• W1980214977 startingPage "278" @default.
• W1980214977 abstract "HIV-1 has evolved several strategies to subvert host immune responses to the infected cells. One is to inhibit CTL recognition by HIV-1 Nef-mediated down-regulation of MHC-I expression on the surface of infected cells. Here we report that Nef also reduces the expression of the non-classical MHC-I like CD1d molecule, a third lineage of antigen-presenting molecule, which presents lipid antigens. Nef achieves this by increasing internalization of CD1d molecules from the cell surface and retaining CD1d in the trans-Golgi-network (TGN). This effect depends on a tyrosine-based motif present in CD1 cytoplasmic tail as well as the actions of four Nef motifs, which are known to be involved in the down-regulation of MHC-I or CD4. These results suggest that Nef regulates intracellular trafficking of CD1d via a distinct but shared pathway with MHC-I and CD4. Thus, HIV-1 reduces the visibility of its infected cells not only to MHC-I-restricted T cells but also to CD1d-restricted NKT cells. Given that CD1d-restricted T cells have unique effector and regulatory functions in innate and adapted immune responses as compared with their counterpart MHC-restricted T cells, our data provide additional new insights into molecular basis of HIV-1-mediated damage to the immune system." @default.
• W1980214977 created "2016-06-24" @default.
• W1980214977 creator A5007734558 @default.
• W1980214977 creator A5041972486 @default.
• W1980214977 creator A5042696398 @default.
• W1980214977 creator A5048100317 @default.
• W1980214977 creator A5068458400 @default.
• W1980214977 creator A5077423550 @default.
• W1980214977 creator A5077510125 @default.
• W1980214977 creator A5088147193 @default.
• W1980214977 date "2006-02-01" @default.
• W1980214977 modified "2023-10-16" @default.
• W1980214977 title "HIV-1 down-regulates the expression of CD1d via Nef" @default.
• W1980214977 cites W1524602398 @default.
• W1980214977 cites W1538716250 @default.
• W1980214977 cites W1548280824 @default.
• W1980214977 cites W1966344619 @default.
• W1980214977 cites W1969436018 @default.
• W1980214977 cites W2004060523 @default.
• W1980214977 cites W2012690743 @default.
• W1980214977 cites W2023991533 @default.
• W1980214977 cites W2030106757 @default.
• W1980214977 cites W2034207391 @default.
• W1980214977 cites W2046964097 @default.
• W1980214977 cites W2050475877 @default.
• W1980214977 cites W2050647563 @default.
• W1980214977 cites W2064608584 @default.
• W1980214977 cites W2069858974 @default.
• W1980214977 cites W2093497258 @default.
• W1980214977 cites W2094741883 @default.
• W1980214977 cites W2112612176 @default.
• W1980214977 cites W2143614051 @default.
• W1980214977 cites W2147258683 @default.
• W1980214977 cites W2148115090 @default.
• W1980214977 cites W2170818228 @default.
• W1980214977 cites W3149762857 @default.
• W1980214977 doi "https://doi.org/10.1002/eji.200535487" @default.
• W1980214977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16385629" @default.
• W1980214977 hasPublicationYear "2006" @default.
• W1980214977 type Work @default.
• W1980214977 sameAs 1980214977 @default.
• W1980214977 citedByCount "121" @default.
• W1980214977 countsByYear W19802149772012 @default.
• W1980214977 countsByYear W19802149772013 @default.
• W1980214977 countsByYear W19802149772014 @default.
• W1980214977 countsByYear W19802149772015 @default.
• W1980214977 countsByYear W19802149772016 @default.
• W1980214977 countsByYear W19802149772017 @default.
• W1980214977 countsByYear W19802149772018 @default.
• W1980214977 countsByYear W19802149772019 @default.
• W1980214977 countsByYear W19802149772020 @default.
• W1980214977 countsByYear W19802149772021 @default.
• W1980214977 countsByYear W19802149772022 @default.
• W1980214977 countsByYear W19802149772023 @default.
• W1980214977 crossrefType "journal-article" @default.
• W1980214977 hasAuthorship W1980214977A5007734558 @default.
• W1980214977 hasAuthorship W1980214977A5041972486 @default.
• W1980214977 hasAuthorship W1980214977A5042696398 @default.
• W1980214977 hasAuthorship W1980214977A5048100317 @default.
• W1980214977 hasAuthorship W1980214977A5068458400 @default.
• W1980214977 hasAuthorship W1980214977A5077423550 @default.
• W1980214977 hasAuthorship W1980214977A5077510125 @default.
• W1980214977 hasAuthorship W1980214977A5088147193 @default.
• W1980214977 hasBestOaLocation W19802149771 @default.
• W1980214977 hasConcept C139563560 @default.
• W1980214977 hasConcept C147483822 @default.
• W1980214977 hasConcept C170627219 @default.
• W1980214977 hasConcept C203014093 @default.
• W1980214977 hasConcept C207936829 @default.
• W1980214977 hasConcept C2776090121 @default.
• W1980214977 hasConcept C2778607024 @default.
• W1980214977 hasConcept C37386791 @default.
• W1980214977 hasConcept C86803240 @default.
• W1980214977 hasConcept C8891405 @default.
• W1980214977 hasConcept C95444343 @default.
• W1980214977 hasConceptScore W1980214977C139563560 @default.
• W1980214977 hasConceptScore W1980214977C147483822 @default.
• W1980214977 hasConceptScore W1980214977C170627219 @default.
• W1980214977 hasConceptScore W1980214977C203014093 @default.
• W1980214977 hasConceptScore W1980214977C207936829 @default.
• W1980214977 hasConceptScore W1980214977C2776090121 @default.
• W1980214977 hasConceptScore W1980214977C2778607024 @default.
• W1980214977 hasConceptScore W1980214977C37386791 @default.
• W1980214977 hasConceptScore W1980214977C86803240 @default.
• W1980214977 hasConceptScore W1980214977C8891405 @default.
• W1980214977 hasConceptScore W1980214977C95444343 @default.
• W1980214977 hasIssue "2" @default.
• W1980214977 hasLocation W19802149771 @default.
• W1980214977 hasLocation W19802149772 @default.
• W1980214977 hasOpenAccess W1980214977 @default.
• W1980214977 hasPrimaryLocation W19802149771 @default.
• W1980214977 hasRelatedWork W146728918 @default.
• W1980214977 hasRelatedWork W2023401063 @default.
• W1980214977 hasRelatedWork W2036575628 @default.
• W1980214977 hasRelatedWork W2125401864 @default.
• W1980214977 hasRelatedWork W2150967155 @default.
• W1980214977 hasRelatedWork W2581148273 @default.
• W1980214977 hasRelatedWork W2783697011 @default.

• next