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- W1980218437 abstract "Abstract The dermal penetration of 2,4-D, cyhexatin, fenvalerate, paraquat, maleic hydrazide, and captan was determined at 1, 6, and 24 hr after application to a 1.2-cm2 area of the upperback of 7- to 8-week-old mice (1 mg/kg). The amounts of labeled pesticide were measured at the site of application and in the blood, liver, kidney, excreta, and carcass. Ninety-five percent, or greater, were recovered in all cases. These compounds were found to penetrate much slower (21% or less in 24 hr) than was shown for a group of insecticides (parathion, permethrin, carbofuran, and dieldrin, for example) in previous reports. Whereas slow penetration could be explained by low partition coefficients for most compounds, both fenvalerate and cyhexatin (high lipophilicity) were also found to have slow penetration rates. These compounds did not indicate any propensity for appreciable storage or binding in the tissues examined. The carcass contained the greatest amount of radioactivity at 24 hr. The fraction of each compound that penetrated was eliminated from the body at various rates with excretion being lowest for paraquat (50%) and highest for 2,4-D (93%) at 24 hr." @default.
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- W1980218437 date "1985-08-01" @default.
- W1980218437 modified "2023-10-07" @default.
- W1980218437 title "Dermal absorption of pesticides in mice" @default.
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- W1980218437 doi "https://doi.org/10.1016/0048-3575(85)90121-x" @default.
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