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• W1980219612 abstract "Background In human Estrogen Receptor α (ERα)-positive breast cancers, 5′ end dense methylation of the estrogen-regulated pS2/TFF1 gene correlates with its transcriptional inhibition. However, in some ERα-rich biopsies, pS2 expression is observed despite the methylation of its TATA-box region. Herein, we investigated the methylation-dependent mechanism of pS2 regulation. Methodology/Principal Findings We observed interplay between Methyl-CpG Binding Domain protein 2 (MBD2) transcriptional repressor and ERα transactivator: (i) the pS2 gene is poised for transcription upon demethylation limited to the enhancer region containing the estrogen responsive element (ERE); (ii) MBD2-binding sites overlapped with the methylation status of the pS2 5′ end; (iii) MBD2 depletion elevated pS2 expression and ectopic expression of ERα partially overcame the inhibitory effect of MBD2 when the ERE is unmethylated. Furthermore, serial chromatin immunoprecipitation assays indicated that MBD2 and ERα could simultaneously occupy the same pS2 DNA molecule; (iv) concomitant ectopic ERα expression and MBD2 depletion resulted in synergistic transcriptional stimulation, while the pS2 promoter remains methylated. Conclusions/Significance MBD2 and ERα drive opposite effects on pS2 expression, which are associated with specific steady state levels of histone H3 acetylation and methylation marks. Thus, epigenetic silencing of pS2 could be dependent on balance of the relative intracellular concentrations of ERα and MBD2." @default.
• W1980219612 created "2016-06-24" @default.
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• W1980219612 date "2010-03-12" @default.
• W1980219612 modified "2023-10-14" @default.
• W1980219612 title "A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene" @default.
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• W1980219612 doi "https://doi.org/10.1371/journal.pone.0009665" @default.
• W1980219612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2837351" @default.
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