Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980228734> ?p ?o ?g. }
- W1980228734 endingPage "e109" @default.
- W1980228734 startingPage "e109" @default.
- W1980228734 abstract "Both theoretical predictions and experimental findings suggest that T cell populations can compete with each other. There is some debate on whether T cells compete for aspecific stimuli, such as access to the surface on antigen-presenting cells (APCs) or for specific stimuli, such as their cognate epitope ligand. We have developed an individual-based computer simulation model to study T cell competition. Our model shows that the expression level of foreign epitopes per APC determines whether T cell competition is mainly for specific or aspecific stimuli. Under low epitope expression, competition is mainly for the specific epitope stimuli, and, hence, different epitope-specific T cell populations coexist readily. However, if epitope expression levels are high, aspecific competition becomes more important. Such between-specificity competition can lead to competitive exclusion between different epitope-specific T cell populations. Our model allows us to delineate the circumstances that facilitate coexistence of T cells of different epitope specificity. Understanding mechanisms of T cell coexistence has important practical implications for immune therapies that require a broad immune response." @default.
- W1980228734 created "2016-06-24" @default.
- W1980228734 creator A5003685863 @default.
- W1980228734 creator A5010649096 @default.
- W1980228734 creator A5054236642 @default.
- W1980228734 date "2006-08-18" @default.
- W1980228734 modified "2023-10-02" @default.
- W1980228734 title "High Epitope Expression Levels Increase Competition between T Cells" @default.
- W1980228734 cites W1482928030 @default.
- W1980228734 cites W1507800008 @default.
- W1980228734 cites W1547859938 @default.
- W1980228734 cites W1555174324 @default.
- W1980228734 cites W1654634869 @default.
- W1980228734 cites W1892909481 @default.
- W1980228734 cites W1916480769 @default.
- W1980228734 cites W1930436120 @default.
- W1980228734 cites W1951894072 @default.
- W1980228734 cites W1965452759 @default.
- W1980228734 cites W1969788040 @default.
- W1980228734 cites W1985080255 @default.
- W1980228734 cites W1986203187 @default.
- W1980228734 cites W1990458269 @default.
- W1980228734 cites W1994837401 @default.
- W1980228734 cites W1995377723 @default.
- W1980228734 cites W1996464851 @default.
- W1980228734 cites W1997303313 @default.
- W1980228734 cites W1997946355 @default.
- W1980228734 cites W1998048927 @default.
- W1980228734 cites W2001651366 @default.
- W1980228734 cites W2008153236 @default.
- W1980228734 cites W2008799315 @default.
- W1980228734 cites W2009115410 @default.
- W1980228734 cites W2015326650 @default.
- W1980228734 cites W2015776459 @default.
- W1980228734 cites W2016285781 @default.
- W1980228734 cites W2018855913 @default.
- W1980228734 cites W2020491131 @default.
- W1980228734 cites W2021673674 @default.
- W1980228734 cites W2025912300 @default.
- W1980228734 cites W2032196578 @default.
- W1980228734 cites W2033374207 @default.
- W1980228734 cites W2039848934 @default.
- W1980228734 cites W2042487497 @default.
- W1980228734 cites W2045209342 @default.
- W1980228734 cites W2052646126 @default.
- W1980228734 cites W2055495862 @default.
- W1980228734 cites W2056167267 @default.
- W1980228734 cites W2057906795 @default.
- W1980228734 cites W2064593553 @default.
- W1980228734 cites W2068494547 @default.
- W1980228734 cites W2073551846 @default.
- W1980228734 cites W2074508421 @default.
- W1980228734 cites W2078387120 @default.
- W1980228734 cites W2079504777 @default.
- W1980228734 cites W2083331853 @default.
- W1980228734 cites W2085412899 @default.
- W1980228734 cites W2085919513 @default.
- W1980228734 cites W2086021932 @default.
- W1980228734 cites W2087484510 @default.
- W1980228734 cites W2091956098 @default.
- W1980228734 cites W2095241459 @default.
- W1980228734 cites W2097398162 @default.
- W1980228734 cites W2098076952 @default.
- W1980228734 cites W2099981310 @default.
- W1980228734 cites W2105996171 @default.
- W1980228734 cites W2106802277 @default.
- W1980228734 cites W2107012083 @default.
- W1980228734 cites W2108909957 @default.
- W1980228734 cites W2110459643 @default.
- W1980228734 cites W2112111895 @default.
- W1980228734 cites W2120333669 @default.
- W1980228734 cites W2121037457 @default.
- W1980228734 cites W2122865615 @default.
- W1980228734 cites W2123096807 @default.
- W1980228734 cites W2130446440 @default.
- W1980228734 cites W2133866490 @default.
- W1980228734 cites W2136601877 @default.
- W1980228734 cites W2137206510 @default.
- W1980228734 cites W2141205048 @default.
- W1980228734 cites W2157772287 @default.
- W1980228734 cites W2160822174 @default.
- W1980228734 cites W2161088539 @default.
- W1980228734 cites W2161321409 @default.
- W1980228734 cites W2162424523 @default.
- W1980228734 cites W2164254316 @default.
- W1980228734 cites W2170831273 @default.
- W1980228734 doi "https://doi.org/10.1371/journal.pcbi.0020109" @default.
- W1980228734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1550274" @default.
- W1980228734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16933984" @default.
- W1980228734 hasPublicationYear "2006" @default.
- W1980228734 type Work @default.
- W1980228734 sameAs 1980228734 @default.
- W1980228734 citedByCount "22" @default.
- W1980228734 countsByYear W19802287342012 @default.
- W1980228734 countsByYear W19802287342013 @default.
- W1980228734 countsByYear W19802287342014 @default.
- W1980228734 countsByYear W19802287342018 @default.
- W1980228734 countsByYear W19802287342019 @default.