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- W1980229791 abstract "Abstract The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies. [Cancer Res 2009;69(20):OF7899–901]" @default.
- W1980229791 created "2016-06-24" @default.
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- W1980229791 date "2009-10-14" @default.
- W1980229791 modified "2023-09-23" @default.
- W1980229791 title "Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat" @default.
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- W1980229791 doi "https://doi.org/10.1158/0008-5472.can-09-1704" @default.
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