Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980229872> ?p ?o ?g. }
- W1980229872 endingPage "S84" @default.
- W1980229872 startingPage "S76" @default.
- W1980229872 abstract "Liver gene therapy is being developed as an alternative to orthotopic liver transplantation, which is the only effective therapy for many liver diseases. The liver has unique features that make it attractive for in vivo and ex vivo gene transfer. In vivo approach is far less invasive than ex vivo approach, although in most cases, host immune response directed against the transgene product and/or vector particles severely impairs the efficiency of gene transfer, and precludes long-term transgene expression after in vivo gene delivery. Ex vivo approach allows for an elective targeting of the hepatocytes, avoiding that the transgene be expressed in professional antigen-presenting, but is faced with the low in vitro proliferative ability of hepatocytes, and to the low in vivo liver repopulating ability of transplanted cells. In some specific situations where immune response was controlled or transplanted cells had a strong growth advantage over host hepatocytes, gene transfer resulted in long-term and complete correction of a liver genetic defect. In this review, we will outline the liver diseases that may benefit from gene therapy, the vector technology under investigation, the advances and the problems to be overcome." @default.
- W1980229872 created "2016-06-24" @default.
- W1980229872 creator A5034824995 @default.
- W1980229872 creator A5088233362 @default.
- W1980229872 date "2004-09-29" @default.
- W1980229872 modified "2023-10-16" @default.
- W1980229872 title "Liver gene therapy: advances and hurdles" @default.
- W1980229872 cites W1579215839 @default.
- W1980229872 cites W1588557264 @default.
- W1980229872 cites W1588659566 @default.
- W1980229872 cites W183310730 @default.
- W1980229872 cites W1942870285 @default.
- W1980229872 cites W1972633462 @default.
- W1980229872 cites W1973278012 @default.
- W1980229872 cites W1974303227 @default.
- W1980229872 cites W1978880070 @default.
- W1980229872 cites W1979686921 @default.
- W1980229872 cites W1980283599 @default.
- W1980229872 cites W1980584105 @default.
- W1980229872 cites W1982729488 @default.
- W1980229872 cites W1989721672 @default.
- W1980229872 cites W1992628415 @default.
- W1980229872 cites W1995612506 @default.
- W1980229872 cites W1997482819 @default.
- W1980229872 cites W2003850761 @default.
- W1980229872 cites W2004818604 @default.
- W1980229872 cites W2009727166 @default.
- W1980229872 cites W2011762615 @default.
- W1980229872 cites W2011767474 @default.
- W1980229872 cites W2012858542 @default.
- W1980229872 cites W2013195094 @default.
- W1980229872 cites W2013359336 @default.
- W1980229872 cites W2014091212 @default.
- W1980229872 cites W2014283098 @default.
- W1980229872 cites W2016823790 @default.
- W1980229872 cites W2018858097 @default.
- W1980229872 cites W2020530842 @default.
- W1980229872 cites W2023184383 @default.
- W1980229872 cites W2024397909 @default.
- W1980229872 cites W2025596234 @default.
- W1980229872 cites W2026893878 @default.
- W1980229872 cites W2027509829 @default.
- W1980229872 cites W2027980120 @default.
- W1980229872 cites W2028480209 @default.
- W1980229872 cites W2033753621 @default.
- W1980229872 cites W2034575324 @default.
- W1980229872 cites W2039913580 @default.
- W1980229872 cites W2040386532 @default.
- W1980229872 cites W2040582632 @default.
- W1980229872 cites W2041782496 @default.
- W1980229872 cites W2042666390 @default.
- W1980229872 cites W2045418359 @default.
- W1980229872 cites W2045762602 @default.
- W1980229872 cites W2046421292 @default.
- W1980229872 cites W2047347790 @default.
- W1980229872 cites W2048949957 @default.
- W1980229872 cites W2052272685 @default.
- W1980229872 cites W2053957384 @default.
- W1980229872 cites W2058848231 @default.
- W1980229872 cites W2062723580 @default.
- W1980229872 cites W2064744205 @default.
- W1980229872 cites W2065412622 @default.
- W1980229872 cites W2067379696 @default.
- W1980229872 cites W2071236935 @default.
- W1980229872 cites W2073673884 @default.
- W1980229872 cites W2073925443 @default.
- W1980229872 cites W2075545024 @default.
- W1980229872 cites W2078321284 @default.
- W1980229872 cites W2081484258 @default.
- W1980229872 cites W2081583806 @default.
- W1980229872 cites W2089154676 @default.
- W1980229872 cites W2089282501 @default.
- W1980229872 cites W2089582480 @default.
- W1980229872 cites W2091346098 @default.
- W1980229872 cites W2093399230 @default.
- W1980229872 cites W2094646089 @default.
- W1980229872 cites W2095019913 @default.
- W1980229872 cites W2097808270 @default.
- W1980229872 cites W2100322240 @default.
- W1980229872 cites W2103833544 @default.
- W1980229872 cites W2105616717 @default.
- W1980229872 cites W2105856585 @default.
- W1980229872 cites W2107121507 @default.
- W1980229872 cites W2110649813 @default.
- W1980229872 cites W2111279074 @default.
- W1980229872 cites W2115772492 @default.
- W1980229872 cites W2120072271 @default.
- W1980229872 cites W2122874617 @default.
- W1980229872 cites W2137440275 @default.
- W1980229872 cites W2137597973 @default.
- W1980229872 cites W2138084195 @default.
- W1980229872 cites W2140508482 @default.
- W1980229872 cites W2141474527 @default.
- W1980229872 cites W2160327135 @default.
- W1980229872 cites W2160641725 @default.
- W1980229872 cites W2166797660 @default.
- W1980229872 cites W2171021135 @default.
- W1980229872 cites W2319603585 @default.