Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980237894> ?p ?o ?g. }
- W1980237894 endingPage "287" @default.
- W1980237894 startingPage "281" @default.
- W1980237894 abstract "Objective: Elevation of several molecular markers of the haemostatic/fibrinolytic system and of soluble adhesion molecules has been associated with acute or chronic phases of atherosclerosis. Speculating that markers associated with atherosclerosis would increase with age, we determined the age-dependency of some of these markers in clinically healthy individuals. Methods: 129 healthy persons were enrolled [division: younger (≤34 years)/older group (>34 years)]. Tissue-type plasminogen activator (t-PA) concentration, plasmin/α2-antiplasmin complex (PAP), D-dimer (DD), prothrombin fragment F1+2 (F1+2), thrombin-antithrombin III complex (TAT), soluble (sICAM-1) intercellular adhesion molecule-1, soluble (sVCAM-1) vascular cell adhesion molecule-1 and sP-selectin were measured with enzyme-linked immuno assays, plasminogen activator inhibitor-1 (PAI-1), plasma kallikrein-like activity (KK), and factor XII (FXII) with chromogenic substrate tests, fibrinogen with the Clauss method. Results: Fibrinogen (P < 0.01), F1+2 (P<0.01), KK (P<0.05) were significantly higher in the older vs. the younger group and correlated significantly with age (P<0.05, P<0.01). DD showed significantly higher values in the older vs. the younger group, whereas T-PA, PAP, FXII, TAT did not. PAI-1 tended towards higher values in the older vs. the younger persons. T-PA, PAI-1, DD correlated significantly with age P-selectin, sICAM-1, sVCAM-1 did not differ between both groups, nor could a significant age-dependency be found. Conclusion: This study indicates that plasma levels of several molecular markers of the haemostatic and fibrinolytic system increase with age. The age-dependency of these markers has to be taken into account in respect to their clinical use in order to characterize patients with suspected risk of atherosclerotic events." @default.
- W1980237894 created "2016-06-24" @default.
- W1980237894 creator A5015031603 @default.
- W1980237894 creator A5022421714 @default.
- W1980237894 creator A5045329970 @default.
- W1980237894 creator A5052286949 @default.
- W1980237894 creator A5053686872 @default.
- W1980237894 creator A5057316972 @default.
- W1980237894 creator A5062090567 @default.
- W1980237894 creator A5074965863 @default.
- W1980237894 date "2000-09-01" @default.
- W1980237894 modified "2023-09-27" @default.
- W1980237894 title "Age-dependency in molecular markers of haemostasis, fibrinolysis and in soluble adhesion molecules" @default.
- W1980237894 cites W1651383390 @default.
- W1980237894 cites W1963936317 @default.
- W1980237894 cites W1964132739 @default.
- W1980237894 cites W1981517237 @default.
- W1980237894 cites W1983338308 @default.
- W1980237894 cites W1989683612 @default.
- W1980237894 cites W1995024643 @default.
- W1980237894 cites W1997379663 @default.
- W1980237894 cites W2005714515 @default.
- W1980237894 cites W2006756692 @default.
- W1980237894 cites W2010686891 @default.
- W1980237894 cites W2015338993 @default.
- W1980237894 cites W2019875318 @default.
- W1980237894 cites W2021081887 @default.
- W1980237894 cites W2032207767 @default.
- W1980237894 cites W2039831544 @default.
- W1980237894 cites W2040408229 @default.
- W1980237894 cites W2040826370 @default.
- W1980237894 cites W2044657425 @default.
- W1980237894 cites W2045075127 @default.
- W1980237894 cites W2047172923 @default.
- W1980237894 cites W2051940847 @default.
- W1980237894 cites W2057492075 @default.
- W1980237894 cites W2062893657 @default.
- W1980237894 cites W2072737535 @default.
- W1980237894 cites W2076500453 @default.
- W1980237894 cites W2078471413 @default.
- W1980237894 cites W2084124265 @default.
- W1980237894 cites W2094832783 @default.
- W1980237894 cites W2095282566 @default.
- W1980237894 cites W2107908226 @default.
- W1980237894 cites W2110185147 @default.
- W1980237894 cites W2114917163 @default.
- W1980237894 cites W2124297695 @default.
- W1980237894 cites W2127474796 @default.
- W1980237894 cites W2128256270 @default.
- W1980237894 cites W2163203265 @default.
- W1980237894 cites W2164162150 @default.
- W1980237894 cites W21802224 @default.
- W1980237894 cites W2284171941 @default.
- W1980237894 cites W2300589760 @default.
- W1980237894 cites W2319725186 @default.
- W1980237894 cites W2324841714 @default.
- W1980237894 cites W2331879659 @default.
- W1980237894 cites W2398217550 @default.
- W1980237894 cites W2399740747 @default.
- W1980237894 cites W2411142063 @default.
- W1980237894 cites W4237645250 @default.
- W1980237894 cites W4294570513 @default.
- W1980237894 cites W4299439003 @default.
- W1980237894 cites W63142751 @default.
- W1980237894 doi "https://doi.org/10.1054/fipr.2000.0082" @default.
- W1980237894 hasPublicationYear "2000" @default.
- W1980237894 type Work @default.
- W1980237894 sameAs 1980237894 @default.
- W1980237894 citedByCount "1" @default.
- W1980237894 crossrefType "journal-article" @default.
- W1980237894 hasAuthorship W1980237894A5015031603 @default.
- W1980237894 hasAuthorship W1980237894A5022421714 @default.
- W1980237894 hasAuthorship W1980237894A5045329970 @default.
- W1980237894 hasAuthorship W1980237894A5052286949 @default.
- W1980237894 hasAuthorship W1980237894A5053686872 @default.
- W1980237894 hasAuthorship W1980237894A5057316972 @default.
- W1980237894 hasAuthorship W1980237894A5062090567 @default.
- W1980237894 hasAuthorship W1980237894A5074965863 @default.
- W1980237894 hasConcept C126322002 @default.
- W1980237894 hasConcept C134018914 @default.
- W1980237894 hasConcept C16224149 @default.
- W1980237894 hasConcept C181199279 @default.
- W1980237894 hasConcept C185592680 @default.
- W1980237894 hasConcept C203014093 @default.
- W1980237894 hasConcept C2776825266 @default.
- W1980237894 hasConcept C2779036427 @default.
- W1980237894 hasConcept C2779519742 @default.
- W1980237894 hasConcept C2779679481 @default.
- W1980237894 hasConcept C2781071845 @default.
- W1980237894 hasConcept C55493867 @default.
- W1980237894 hasConcept C71924100 @default.
- W1980237894 hasConceptScore W1980237894C126322002 @default.
- W1980237894 hasConceptScore W1980237894C134018914 @default.
- W1980237894 hasConceptScore W1980237894C16224149 @default.
- W1980237894 hasConceptScore W1980237894C181199279 @default.
- W1980237894 hasConceptScore W1980237894C185592680 @default.
- W1980237894 hasConceptScore W1980237894C203014093 @default.
- W1980237894 hasConceptScore W1980237894C2776825266 @default.