FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980239164> ?p ?o ?g. }

• W1980239164 endingPage "20332" @default.
• W1980239164 startingPage "20321" @default.
• W1980239164 abstract "The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is unknown. We report here that induction of ER stress with either thapsigargin or tunicamycin in mouse embryonic fibroblasts leads to up-regulation of Mfn2 mRNA and protein levels with no change in the expression of the mitochondrial shaping factors Mfn1, Opa1, Drp1, and Fis1. Genetic deletion of Mfn2 but not Mfn1 in mouse embryonic fibroblasts or cardiac myocytes in mice led to an increase in the expression of the ER chaperone proteins. Genetic ablation of Mfn2 in mouse embryonic fibroblasts amplified ER stress and exacerbated ER stress-induced apoptosis. Deletion of Mfn2 delayed translational recovery through prolonged eIF2α phosphorylation associated with decreased GADD34 and p58(IPK) expression and elevated C/EBP homologous protein induction at late time points. These changes in the unfolded protein response were coupled to increased cell death reflected by augmented caspase 3/7 activity, lactate dehydrogenase release from cells, and an increase in propidium iodide-positive nuclei in response to thapsigargin or tunicamycin treatment. In contrast, genetic deletion of Mfn1 did not affect ER stress-mediated increase in ER chaperone synthesis or eIF2α phosphorylation. Additionally, ER stress-induced C/EBP homologous protein, GADD34, and p58(IPK) induction and cell death were not affected by loss of Mfn1. We conclude that Mfn2 but not Mfn1 is an ER stress-inducible protein that is required for the proper temporal sequence of the ER stress response." @default.
• W1980239164 created "2016-06-24" @default.
• W1980239164 creator A5060967318 @default.
• W1980239164 creator A5072223969 @default.
• W1980239164 creator A5084277519 @default.
• W1980239164 date "2012-06-01" @default.
• W1980239164 modified "2023-10-14" @default.
• W1980239164 title "Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress" @default.
• W1980239164 cites W1505761263 @default.
• W1980239164 cites W1546139069 @default.
• W1980239164 cites W1570888466 @default.
• W1980239164 cites W1599264286 @default.
• W1980239164 cites W1967659527 @default.
• W1980239164 cites W1970182526 @default.
• W1980239164 cites W1973886069 @default.
• W1980239164 cites W1981737129 @default.
• W1980239164 cites W1986873096 @default.
• W1980239164 cites W1988482079 @default.
• W1980239164 cites W2010442161 @default.
• W1980239164 cites W2015221597 @default.
• W1980239164 cites W2020437934 @default.
• W1980239164 cites W2024397718 @default.
• W1980239164 cites W2024595059 @default.
• W1980239164 cites W2036677133 @default.
• W1980239164 cites W2038481055 @default.
• W1980239164 cites W2041000089 @default.
• W1980239164 cites W2043723940 @default.
• W1980239164 cites W2067701929 @default.
• W1980239164 cites W2069372121 @default.
• W1980239164 cites W2073095545 @default.
• W1980239164 cites W2077784911 @default.
• W1980239164 cites W2088283936 @default.
• W1980239164 cites W2089198803 @default.
• W1980239164 cites W2090512271 @default.
• W1980239164 cites W2090988285 @default.
• W1980239164 cites W2093158584 @default.
• W1980239164 cites W2096321546 @default.
• W1980239164 cites W2100347985 @default.
• W1980239164 cites W2106787957 @default.
• W1980239164 cites W2107030671 @default.
• W1980239164 cites W2107601804 @default.
• W1980239164 cites W2109879006 @default.
• W1980239164 cites W2112286580 @default.
• W1980239164 cites W2112524117 @default.
• W1980239164 cites W2117631316 @default.
• W1980239164 cites W2120736516 @default.
• W1980239164 cites W2127271204 @default.
• W1980239164 cites W2127848114 @default.
• W1980239164 cites W2133644385 @default.
• W1980239164 cites W2135314348 @default.
• W1980239164 cites W2137755719 @default.
• W1980239164 cites W2138718614 @default.
• W1980239164 cites W2142192946 @default.
• W1980239164 cites W2144846851 @default.
• W1980239164 cites W2145112854 @default.
• W1980239164 cites W2145994786 @default.
• W1980239164 cites W2148527632 @default.
• W1980239164 cites W2151698573 @default.
• W1980239164 cites W2152674951 @default.
• W1980239164 cites W2156990953 @default.
• W1980239164 cites W2162294575 @default.
• W1980239164 cites W2164390141 @default.
• W1980239164 cites W2164721799 @default.
• W1980239164 cites W2165064047 @default.
• W1980239164 cites W2166432730 @default.
• W1980239164 cites W2168007689 @default.
• W1980239164 cites W2170781810 @default.
• W1980239164 cites W4253064068 @default.
• W1980239164 doi "https://doi.org/10.1074/jbc.m112.359174" @default.
• W1980239164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3370214" @default.
• W1980239164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22511781" @default.
• W1980239164 hasPublicationYear "2012" @default.
• W1980239164 type Work @default.
• W1980239164 sameAs 1980239164 @default.
• W1980239164 citedByCount "139" @default.
• W1980239164 countsByYear W19802391642012 @default.
• W1980239164 countsByYear W19802391642013 @default.
• W1980239164 countsByYear W19802391642014 @default.
• W1980239164 countsByYear W19802391642015 @default.
• W1980239164 countsByYear W19802391642016 @default.
• W1980239164 countsByYear W19802391642017 @default.
• W1980239164 countsByYear W19802391642018 @default.
• W1980239164 countsByYear W19802391642019 @default.
• W1980239164 countsByYear W19802391642020 @default.
• W1980239164 countsByYear W19802391642021 @default.
• W1980239164 countsByYear W19802391642022 @default.
• W1980239164 countsByYear W19802391642023 @default.
• W1980239164 crossrefType "journal-article" @default.
• W1980239164 hasAuthorship W1980239164A5060967318 @default.
• W1980239164 hasAuthorship W1980239164A5072223969 @default.
• W1980239164 hasAuthorship W1980239164A5084277519 @default.
• W1980239164 hasBestOaLocation W19802391641 @default.
• W1980239164 hasConcept C104317684 @default.
• W1980239164 hasConcept C139447449 @default.
• W1980239164 hasConcept C158617107 @default.
• W1980239164 hasConcept C163950672 @default.
• W1980239164 hasConcept C24586158 @default.
• W1980239164 hasConcept C2777092462 @default.

• next