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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980240337> ?p ?o ?g. }

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• W1980240337 abstract "C-6 Biarylmethylamino purine derivatives of roscovitine (1) inhibit cyclin dependent kinases and demonstrate potent antiproliferative activity. Replacement of the aryl rings of the C-6 biarylmethylamino group with heterobiaryl rings has provided compounds with significantly improved activity. In particular, derivatives 18g and 9c demonstrated 1000-fold and 1250-fold improvements, respectively, in the growth inhibition of HeLa cells compared to roscovitine (1)." @default.
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• W1980240337 date "2009-12-01" @default.
• W1980240337 modified "2023-09-27" @default.
• W1980240337 title "Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II" @default.
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• W1980240337 doi "https://doi.org/10.1016/j.bmcl.2009.10.011" @default.
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