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• W1980254110 abstract "Little is known about long-term outcomes in patients who experience infusion reactions while receiving infliximab.To investigate long-term outcomes in patients who experience infusion reactions while receiving infliximab.Retrospective electronic chart review of long-term clinical outcomes.Clinical data on 287 patients who received infliximab infusions for Crohn's disease were reviewed, of whom 51 developed at least one infusion reaction (18%). Ileo-colonic disease (OR 2.2, 95% CI 1.1-4.4) and episodic infliximab (OR 2.4, 95% CI 1.2-4.7) were associated with a higher risk of infusion reactions in univariate analysis, but concomitant azathioprine/mercaptopurine therapy at the initiation of infliximab was associated with a reduced risk (OR 0.4, 95% CI 0.2-0.8). Only the effect of concomitant immunomodulators persisted on multivariate analysis. Patients who experienced infusion reactions were less likely to be in remission at 1 year (OR 0.6, 95% CI 0.3-1.2), 2 years (OR 0.4, 95% CI 0.2-0.8, P = 0.01), or 5 years (OR 0.4, 95% CI 0.1-1.3) and more likely to require surgery (OR 2.2, 95% CI 1.1-4.1, P = 0.01) than those who did not experience such reactions.Patients who experienced infusion reactions to infliximab had a high rate of discontinuation of therapy in this cohort. Concomitant immunomodulators and maintenance therapy reduced the risk of infusion reactions." @default.
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• W1980254110 date "2008-06-28" @default.
• W1980254110 modified "2023-10-15" @default.
• W1980254110 title "The impact of infliximab infusion reactions on long-term outcomes in patients with Crohn’s disease" @default.
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• W1980254110 doi "https://doi.org/10.1111/j.1365-2036.2008.03734.x" @default.
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