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- W1980273002 abstract "Conflict of interest: none declared. Dapsone, traditionally an antileprotic agent, is useful in a range of dermatological conditions including bullous disorders such as dermatitis herpetiformis and linear IgA disease, and in several other inflammatory dermatoses. However, it is known to cause dose‐dependent haemolysis and methaemoglobinaemia, and regular blood monitoring of patients on treatment is needed to promptly detect and treat these potentially life‐threatening side‐effects. A 77‐year‐old man with chronic obstructive pulmonary diseases who was on long‐term oxygen treatments was admitted to our hospital with extensive intact blisters and erosions on the skin, with involvement of the mucous membranes. Histological examination of a skin biopsy and immunofluorescence tests showed changes consistent with mucous membrane pemphigoid. The disease proved difficult to control despite treatment with high‐dose oral steroids, azathioprine and minocin. In addition, the patient developed complications including a chest infection and steroid‐induced diabetes. He was therefore commenced on dapsone (50 mg in the morning, 25 mg at night) in place of azathioprine as a disease‐modifying and steroid‐sparing agent and clinical improvement was noted. His screening blood tests including glucose‐6‐phosphate dehydrogenase levels were normal." @default.
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- W1980273002 date "2009-12-01" @default.
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- W1980273002 title "The use of cimetidine to reduce dapsone-dependent haematological side-effects in a patient with mucous membrane pemphigoid" @default.
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- W1980273002 doi "https://doi.org/10.1111/j.1365-2230.2009.03710.x" @default.
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