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• W1980280188 abstract "Abstract: In the present study, we have investigated the role of Ca2+ in the coupling of membrane depolarization to neurotransmitter secretion. We have measured (a) intracellular free Ca2+ concentration ([Ca2+Ji) changes, (b) rapid 45Ca2+uptake, and (c) Ca2+-dependent and -independent release of endogenous glutamate (Glu) and γ-aminobutyric acid (GABA) as a function of stimulus intensity by elevating the extracellular [K+] to different levels in purified ijierve terminals (synaptosomes) from rat hippocampus. Duriijg stimulation, Percoll-purined synaptosomes show an increased 45Ca2+ uptake, an elevated [Ca2+]i, and a Ca2+-dependejnt as well as a Ca2+-independent release of both Glu and GABA. With respect to both amino acids, synaptosomes respond on stimulation essentially in the same way, with maximally a fourfold increase in Ca2+-dependent (exocytotic) release. Ca2+-depen-dent transmitter release as well as [Ca2+]; elevations show maximal stimulation at moderate depolarizations (30 mM K+). A correlation exists between Ca2+-dependent release of both Glu and GABA and elevation of [Ca2+]i. C2+-dependent release is maximally stimulated with an elevation of [Ca2+]Iof 60% above steady-state levels, corresponding with an intracellular concentration of ∼400 nM, whereas elevations to 350 nM are ineffective in stimulating Ca2+-dependent release of both Glu and GABA. In contrast, Ca2+-independent release of both Glu and GABA shows roughly a linear rise with stimulus intensity up to 50 mM K+. 45Ca2+ uptake on stimulation also shows a continuous increase with stimulus intensity, although the relationship appears to be biphasic, with a plateau between 20 and 40 mM K+. These findings indicate that Ca2+-dependent, exocytotic transmitter release is not simply enhanced by larger depolarizations of the plasma membrane and that a strong Ca2+-dependent regulatory mechanism exists in synaptosomes for the trigger of exocytosis, operating at a mean [Ca2+]i of between 350 and 400 nM. Ca2+ transport and buffering mechanisms possibly involved in this regulation and the role of the membrane potential are discussed." @default.
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• W1980280188 date "1989-10-01" @default.
• W1980280188 modified "2023-09-27" @default.
• W1980280188 title "Ca2+-Dependent Regulation of Presynaptic Stimulus-Secretion Coupling" @default.
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• W1980280188 doi "https://doi.org/10.1111/j.1471-4159.1989.tb07413.x" @default.
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