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• W1980297026 abstract "Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by an overproduction of autoantibodies. The loss of self-tolerance in SLE is believed to be caused by the dysregulation of both innate and adaptive immune systems. Neutrophils, the most abundant effector cells of innate immunity, have long been shown to be associated with SLE. However, their role in the pathogenesis of SLE was not clear until recent studies discovered abnormal regulation of neutrophil extracellular traps (NETs) in SLE patients. NETs are web-like structures composed of chromatin backbones and granular molecules. They are released by activated neutrophils through a process called NETosis. Nets were first described in 2004 as a novel host defense mechanism to trap and kill foreign pathogens. Recent evidence shows that NETs also participate in the pathogenesis of a variety of inflammatory and autoimmune diseases, including SLE. An imbalance between NET formation and clearance in SLE patients may play a prominent role in the perpetuation of autoimmunity and the exacerbation of disease, as well as the induction of end-organ manifestations. This review summarizes the current findings regarding the contribution of NETs to the pathogenesis of SLE." @default.
• W1980297026 created "2016-06-24" @default.
• W1980297026 creator A5023128893 @default.
• W1980297026 creator A5071762821 @default.
• W1980297026 date "2013-01-01" @default.
• W1980297026 modified "2023-10-01" @default.
• W1980297026 title "Neutrophil Extracellular Traps and Systemic Lupus Erythematosus" @default.
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• W1980297026 cites W1831776830 @default.
• W1980297026 cites W186952152 @default.
• W1980297026 cites W1914666406 @default.
• W1980297026 cites W1974317358 @default.
• W1980297026 cites W1978508787 @default.
• W1980297026 cites W1985613212 @default.
• W1980297026 cites W1986282241 @default.
• W1980297026 cites W1987241193 @default.
• W1980297026 cites W1990173822 @default.
• W1980297026 cites W2001328992 @default.
• W1980297026 cites W2002330872 @default.
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• W1980297026 cites W2019916852 @default.
• W1980297026 cites W2029022410 @default.
• W1980297026 cites W2030193400 @default.
• W1980297026 cites W2040252895 @default.
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• W1980297026 cites W2042658627 @default.
• W1980297026 cites W2043756611 @default.
• W1980297026 cites W2045819100 @default.
• W1980297026 cites W2048088767 @default.
• W1980297026 cites W2048801137 @default.
• W1980297026 cites W2050256766 @default.
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• W1980297026 cites W2089770978 @default.
• W1980297026 cites W2091512988 @default.
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• W1980297026 cites W2099356583 @default.
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• W1980297026 doi "https://doi.org/10.4172/2155-9899.1000139" @default.
• W1980297026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3826916" @default.
• W1980297026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24244889" @default.
• W1980297026 hasPublicationYear "2013" @default.
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