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• W1980333973 abstract "N-acetoxy-2-acetlylaminofluorene(N-Ac-AAF) is an alkylating agent that forms DNA adducts at C-8 is guanine and causes single strand breaks. It has abnormal development have not been investigated. Previous studies have indicated that other DNA alkylating agents cause cell death during embryonic development although the types of cell death were not characterized. Using a whole embryo culture system, gestation day 10 rat embryo were exposed to several concentrations (5, 50 and 200 μg/ml)of N-Ac-AAF at several times points after expire was begun (5,10,24 hours), the embryos were removed from culture from culture and examined to identify location, type and quantity of cell death, relative to programmed cell death observed in control embryos. Vital staining with Nile blue sulphate revealed that the location of N-Ac-AAf- include cell death included the forebrain region, tail and areas of programmed cell death Examination of tissue section from both control and treated embryos indicated that the location of apoptotic cell death revealed by in situ DNA nick end -labelling was generally consistent with the cell death pattern observed by vital staining of whole embryos. Agarose gel analyses indicated that all concentration of N-Ac-AAF caused DNA fragmentation, and Quantification demonstrated a dose response. Examination of treated embryos (50 and 200μg/ ml) by transmission electron microscopy revealed that, by 5 hours after exposure, cells with class, ultrastructural features of apoptosis were present. In conclusion, multiple method have all indicated that, regardless of exposure level, apoptosis was the predominant from of cell death. Because opotosis also occurs in developmental cell death, it is possible that apotosis induced by N-Ac-AAF is due to an alternation in cell fate via premature or ectopic induced of the cell death program. © 1995 Wiley-Liss, Inc." @default.
• W1980333973 created "2016-06-24" @default.
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• W1980333973 date "1995-06-01" @default.
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• W1980333973 title "Programmed cell death and N-acetoxy-2-acetylaminofluorene-induced apoptosis in the rat embryo" @default.
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• W1980333973 doi "https://doi.org/10.1002/tera.1420510607" @default.
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