FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980334501> ?p ?o ?g. }

• W1980334501 endingPage "9647" @default.
• W1980334501 startingPage "9642" @default.
• W1980334501 abstract "Redistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that acquisition of a motile phenotype in T lymphocytes results in the asymmetric redistribution of ganglioside GM3- and GM1-enriched raft domains to the leading edge and to the uropod, respectively. This segregation to each cell pole parallels the specific redistribution of membrane proteins associated to each raft subfraction. Our data suggest that raft partitioning is a major determinant for protein redistribution in polarized T cells, as ectopic expression of raft-associated proteins results in their asymmetric redistribution, whereas non-raft-partitioned mutants of these proteins are distributed homogeneously in the polarized cell membrane. Both acquisition of a migratory phenotype and SDF-1alpha-induced chemotaxis are cholesterol depletion-sensitive. Finally, GM3 and GM1 raft redistribution requires an intact actin cytoskeleton, but is insensitive to microtubule disruption. We propose that membrane protein segregation not only between raft and nonraft domains but also between distinct raft subdomains may be an organizational principle that mediates redistribution of specialized molecules needed for T cell migration." @default.
• W1980334501 created "2016-06-24" @default.
• W1980334501 creator A5004416971 @default.
• W1980334501 creator A5028742544 @default.
• W1980334501 creator A5030159349 @default.
• W1980334501 creator A5031409611 @default.
• W1980334501 creator A5048129993 @default.
• W1980334501 creator A5051411928 @default.
• W1980334501 creator A5051712299 @default.
• W1980334501 creator A5063642954 @default.
• W1980334501 creator A5071887992 @default.
• W1980334501 creator A5077587097 @default.
• W1980334501 date "2001-08-07" @default.
• W1980334501 modified "2023-10-18" @default.
• W1980334501 title "Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization" @default.
• W1980334501 cites W1492348917 @default.
• W1980334501 cites W1510633975 @default.
• W1980334501 cites W1564861448 @default.
• W1980334501 cites W1845375977 @default.
• W1980334501 cites W1906447044 @default.
• W1980334501 cites W1970067609 @default.
• W1980334501 cites W1975806945 @default.
• W1980334501 cites W1981224888 @default.
• W1980334501 cites W1983558530 @default.
• W1980334501 cites W1988650452 @default.
• W1980334501 cites W1997012892 @default.
• W1980334501 cites W1998217618 @default.
• W1980334501 cites W2008791808 @default.
• W1980334501 cites W2011936885 @default.
• W1980334501 cites W2018088003 @default.
• W1980334501 cites W2034017782 @default.
• W1980334501 cites W2034146282 @default.
• W1980334501 cites W2034316828 @default.
• W1980334501 cites W2034718251 @default.
• W1980334501 cites W2040948261 @default.
• W1980334501 cites W2041247573 @default.
• W1980334501 cites W2049549946 @default.
• W1980334501 cites W2071946819 @default.
• W1980334501 cites W2077192156 @default.
• W1980334501 cites W2080494149 @default.
• W1980334501 cites W2088463353 @default.
• W1980334501 cites W2088733592 @default.
• W1980334501 cites W2102265386 @default.
• W1980334501 cites W2120209561 @default.
• W1980334501 cites W2127792983 @default.
• W1980334501 cites W2134306415 @default.
• W1980334501 cites W2139846514 @default.
• W1980334501 cites W2143992953 @default.
• W1980334501 cites W2143999338 @default.
• W1980334501 cites W2151519283 @default.
• W1980334501 cites W2153052569 @default.
• W1980334501 cites W2153776880 @default.
• W1980334501 cites W2158333423 @default.
• W1980334501 cites W2167230971 @default.
• W1980334501 cites W2342812531 @default.
• W1980334501 cites W4230720953 @default.
• W1980334501 cites W4233669749 @default.
• W1980334501 doi "https://doi.org/10.1073/pnas.171160298" @default.
• W1980334501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55505" @default.
• W1980334501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11493690" @default.
• W1980334501 hasPublicationYear "2001" @default.
• W1980334501 type Work @default.
• W1980334501 sameAs 1980334501 @default.
• W1980334501 citedByCount "476" @default.
• W1980334501 countsByYear W19803345012012 @default.
• W1980334501 countsByYear W19803345012013 @default.
• W1980334501 countsByYear W19803345012014 @default.
• W1980334501 countsByYear W19803345012015 @default.
• W1980334501 countsByYear W19803345012016 @default.
• W1980334501 countsByYear W19803345012017 @default.
• W1980334501 countsByYear W19803345012018 @default.
• W1980334501 countsByYear W19803345012019 @default.
• W1980334501 countsByYear W19803345012020 @default.
• W1980334501 countsByYear W19803345012021 @default.
• W1980334501 countsByYear W19803345012022 @default.
• W1980334501 countsByYear W19803345012023 @default.
• W1980334501 crossrefType "journal-article" @default.
• W1980334501 hasAuthorship W1980334501A5004416971 @default.
• W1980334501 hasAuthorship W1980334501A5028742544 @default.
• W1980334501 hasAuthorship W1980334501A5030159349 @default.
• W1980334501 hasAuthorship W1980334501A5031409611 @default.
• W1980334501 hasAuthorship W1980334501A5048129993 @default.
• W1980334501 hasAuthorship W1980334501A5051411928 @default.
• W1980334501 hasAuthorship W1980334501A5051712299 @default.
• W1980334501 hasAuthorship W1980334501A5063642954 @default.
• W1980334501 hasAuthorship W1980334501A5071887992 @default.
• W1980334501 hasAuthorship W1980334501A5077587097 @default.
• W1980334501 hasBestOaLocation W19803345011 @default.
• W1980334501 hasConcept C12554922 @default.
• W1980334501 hasConcept C137738243 @default.
• W1980334501 hasConcept C142669718 @default.
• W1980334501 hasConcept C1491633281 @default.
• W1980334501 hasConcept C156728348 @default.
• W1980334501 hasConcept C15920480 @default.
• W1980334501 hasConcept C17744445 @default.
• W1980334501 hasConcept C178790620 @default.
• W1980334501 hasConcept C185592680 @default.
• W1980334501 hasConcept C199539241 @default.

• next