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- W1980347162 abstract "A new and efficient synthesis of 4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline dihydrochloride, a key intermediate for the CCR5 antagonist TAK-779, is described. Reductive alkylation of methylamine with tetrahydro-4H-pyran-4-one followed by alkylation of N-methyl-N-(tetrahydropyran-4-yl)amine with 4-nitrobenzylbromide and reduction of N-(4-nitrobenzyl)-N-(tetrahydropyran-4-yl)amine results in a 78% isolated yield from the starting materials by a scalable method, using only commercially available reagents." @default.
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- W1980347162 date "2001-11-30" @default.
- W1980347162 modified "2023-10-18" @default.
- W1980347162 title "Process Development of 4-[<i>N</i>-Methyl-<i>N</i>-(tetrahydropyran-4-yl)aminomethyl]aniline Dihydrochloride: A Key Intermediate for TAK-779, a Small-Molecule Nonpeptide CCR5 Antagonist" @default.
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- W1980347162 doi "https://doi.org/10.1021/op010052o" @default.
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