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• W1980350538 abstract "A series of allelic mutations in the tumor suppressor Brca1 have been created to study mechanisms underlying BRCA1-associated tumorigenesis. Brca1 is essential in maintaining genome integrity through its involvement in DNA damage repair, G(2)-M cell-cycle checkpoint and centrosome duplication. The loss of Brca1 is not sufficient for malignant transformation, rather, it triggers multiple genetic alterations, including the inactivation of p53 and activation of a number of oncogenes, that ultimately result in mammary tumorigenesis." @default.
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• W1980350538 date "2001-10-01" @default.
• W1980350538 modified "2023-10-16" @default.
• W1980350538 title "BRCA1-associated tumorigenesis: what have we learned from knockout mice?" @default.
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• W1980350538 doi "https://doi.org/10.1016/s0168-9525(01)02451-9" @default.
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