Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980373350> ?p ?o ?g. }
- W1980373350 endingPage "4091" @default.
- W1980373350 startingPage "4085" @default.
- W1980373350 abstract "Two novel peptides, ECH (Glu-Cys-His) and YECG (Tyr-Glu-Cys-Gly), were designed based on glutathione (Glu-Cys-Gly, GSH) and their antioxidant activities were studied. Various chemical methods based on single-electron-transfer (SET) and hydrogen-atom-transfer (HAT) were applied to evaluate the antioxidant activities of the peptides. For SET-based assay, tripeptide ECH displayed the highest DPPH radical scavenging activity (80.16%) and the strongest reducing power (A700 = 0.378). Besides, ECH also exhibited the best inhibition activity toward linoleic acid peroxidation with inhibition rate 98.25% at 7th day, which is a HAT-based assay. However, for another two HAT-based assays, it was tetrapeptide YECG that showed extraordinary oxygen radical absorption capacity (ORAC value = 2.42 μM Trolox/μM) and ABTS free radical scavenging ability (8.88 mM Trolox/mM). In vitro cultured PC12 cell model also suggested that YECG gave the best protection for PC12 cells to resist H2O2-treated necrosis. It was found that the discrepancy of antioxidant capacity between ECH and YECG was caused by the presence of antioxidant amino acids (His/Tyr) and their position in peptide chain. With His located at C-terminal position, ECH demonstrated good electrons donating capacity, while with Tyr at N-terminal position, YECG exhibited strong oxygen radical absorbance capacity." @default.
- W1980373350 created "2016-06-24" @default.
- W1980373350 creator A5006356792 @default.
- W1980373350 creator A5022728200 @default.
- W1980373350 creator A5030594524 @default.
- W1980373350 creator A5038203298 @default.
- W1980373350 creator A5058350676 @default.
- W1980373350 creator A5073383142 @default.
- W1980373350 creator A5090656526 @default.
- W1980373350 date "2012-11-01" @default.
- W1980373350 modified "2023-10-13" @default.
- W1980373350 title "Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure" @default.
- W1980373350 cites W1964957521 @default.
- W1980373350 cites W1969471867 @default.
- W1980373350 cites W1978212894 @default.
- W1980373350 cites W1979206097 @default.
- W1980373350 cites W1981667724 @default.
- W1980373350 cites W1991902019 @default.
- W1980373350 cites W1998703766 @default.
- W1980373350 cites W1998936301 @default.
- W1980373350 cites W2005457909 @default.
- W1980373350 cites W2006334095 @default.
- W1980373350 cites W2007482003 @default.
- W1980373350 cites W2012549422 @default.
- W1980373350 cites W2012991711 @default.
- W1980373350 cites W2013343018 @default.
- W1980373350 cites W2014352102 @default.
- W1980373350 cites W2018867961 @default.
- W1980373350 cites W2031636608 @default.
- W1980373350 cites W2038226781 @default.
- W1980373350 cites W2042991061 @default.
- W1980373350 cites W2050929412 @default.
- W1980373350 cites W2052428767 @default.
- W1980373350 cites W2054276115 @default.
- W1980373350 cites W2057434602 @default.
- W1980373350 cites W2058165268 @default.
- W1980373350 cites W2058205370 @default.
- W1980373350 cites W2068875411 @default.
- W1980373350 cites W2076141648 @default.
- W1980373350 cites W2081935293 @default.
- W1980373350 cites W2082784921 @default.
- W1980373350 cites W2091843298 @default.
- W1980373350 cites W2093979148 @default.
- W1980373350 cites W2099476122 @default.
- W1980373350 cites W2108070884 @default.
- W1980373350 cites W2114918609 @default.
- W1980373350 cites W2334202267 @default.
- W1980373350 doi "https://doi.org/10.1016/j.fct.2012.08.028" @default.
- W1980373350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22940538" @default.
- W1980373350 hasPublicationYear "2012" @default.
- W1980373350 type Work @default.
- W1980373350 sameAs 1980373350 @default.
- W1980373350 citedByCount "47" @default.
- W1980373350 countsByYear W19803733502013 @default.
- W1980373350 countsByYear W19803733502014 @default.
- W1980373350 countsByYear W19803733502015 @default.
- W1980373350 countsByYear W19803733502016 @default.
- W1980373350 countsByYear W19803733502017 @default.
- W1980373350 countsByYear W19803733502018 @default.
- W1980373350 countsByYear W19803733502019 @default.
- W1980373350 countsByYear W19803733502020 @default.
- W1980373350 countsByYear W19803733502021 @default.
- W1980373350 countsByYear W19803733502022 @default.
- W1980373350 countsByYear W19803733502023 @default.
- W1980373350 crossrefType "journal-article" @default.
- W1980373350 hasAuthorship W1980373350A5006356792 @default.
- W1980373350 hasAuthorship W1980373350A5022728200 @default.
- W1980373350 hasAuthorship W1980373350A5030594524 @default.
- W1980373350 hasAuthorship W1980373350A5038203298 @default.
- W1980373350 hasAuthorship W1980373350A5058350676 @default.
- W1980373350 hasAuthorship W1980373350A5073383142 @default.
- W1980373350 hasAuthorship W1980373350A5090656526 @default.
- W1980373350 hasConcept C139066938 @default.
- W1980373350 hasConcept C167392928 @default.
- W1980373350 hasConcept C181199279 @default.
- W1980373350 hasConcept C185592680 @default.
- W1980373350 hasConcept C2776188313 @default.
- W1980373350 hasConcept C2776231299 @default.
- W1980373350 hasConcept C2778004101 @default.
- W1980373350 hasConcept C2779281246 @default.
- W1980373350 hasConcept C2780829032 @default.
- W1980373350 hasConcept C2781031786 @default.
- W1980373350 hasConcept C2781401929 @default.
- W1980373350 hasConcept C538909803 @default.
- W1980373350 hasConcept C55493867 @default.
- W1980373350 hasConceptScore W1980373350C139066938 @default.
- W1980373350 hasConceptScore W1980373350C167392928 @default.
- W1980373350 hasConceptScore W1980373350C181199279 @default.
- W1980373350 hasConceptScore W1980373350C185592680 @default.
- W1980373350 hasConceptScore W1980373350C2776188313 @default.
- W1980373350 hasConceptScore W1980373350C2776231299 @default.
- W1980373350 hasConceptScore W1980373350C2778004101 @default.
- W1980373350 hasConceptScore W1980373350C2779281246 @default.
- W1980373350 hasConceptScore W1980373350C2780829032 @default.
- W1980373350 hasConceptScore W1980373350C2781031786 @default.
- W1980373350 hasConceptScore W1980373350C2781401929 @default.
- W1980373350 hasConceptScore W1980373350C538909803 @default.
- W1980373350 hasConceptScore W1980373350C55493867 @default.