FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980388622> ?p ?o ?g. }

• W1980388622 abstract "Single doses of radioantibody are effective at treating single cells or small clusters of cancer cells. However, large tumor masses require either multiple doses of radioantibody or a multimodal approach to therapy using two or more therapeutic agents. Timing of the second dose in a multiple cycle scheme or the second treatment in a multimodal protocol will depend on recovery from toxicity associated with the first treatment.BALB/c mice were dosed with a maximal tolerated dose (MTD) of I-131-MN-14 anti-carcinoembryonic antigen immunoglobulin G (IgG) (250 microCi) or F(ab')2 (1.2 mCi). Mice were redosed with the MTD at one of four time points, either Day 28, 35, 42, or 49 after IgG or Day 14, 21, 28, or 35 after F(ab')2. Survival was monitored to determine the earliest time to redose without lethality. Several studies were then performed to identify an accurate measure of true myelorecovery. Mice were bled retroorbitally on the day of the first dose and at weekly intervals thereafter. Total peripheral white blood cell counts, granulocyte counts, and lymphocyte counts were determined for each animal. GR-1hi expression (percentage of positive cells) and mean channel florescence were determined by FACScan analysis of a blood sample incubated with fluorescein isothiocyanate-anti-mouse Ly-6G (GR-1). In other studies, two mice were killed weekly from a group treated with a single MTD of radioantibody. The weights of their spleens and thymus glands were determined. At that time, femoral marrow was collected from these animals and plated in Methocult M3430 methylcellulose medium (Stemcell Technologies, Vancouver, Canada), and total colony-forming cells in culture were determined. Another population of mice was used to assess normal tissue metabolic activity following radioantibody therapy by quantitating the 4-hour utilization of I-125-dUrd.The ability to redose mice with a second MTD of 1-131-IgG or F(ab')2 required 49 days and 35 days, respectively. Granulocyte and lymphocyte counts did not accurately predict myelorecovery from the first dose. Hematopoietic tissue weight, tissue metabolic activity, and marrow colony forming cells all suggested that redosing was possible 1-2 weeks before it could actually be done without lethality. Percent of cells expressing GR-1hi (>60%) and absolute numbers of GR-1hi cells (>1400 cells/mm3) suggested myelorecovery in most animals. A greater degree of accuracy was achieved when trends in GR-1hi expression were noted over 2 or more weeks (i.e., the absolute amount of GR-1hi had to exceed levels in untreated mice, as evidence that the hyperproliferative phase of recovery was complete).The only approach that accurately predicted the ability to retreat with myelosuppressive therapy without risk of lethality was an increase in GR-1hi-positive cells above untreated levels. Other approaches are currently being investigated, including the expression of proliferation antigens (e.g., proliferating cell nuclear antigen and Ki-67) in both murine and human samples and differentiation antigens (CD33 and CD34) in humans." @default.
• W1980388622 created "2016-06-24" @default.
• W1980388622 creator A5003890903 @default.
• W1980388622 creator A5005893482 @default.
• W1980388622 creator A5043569662 @default.
• W1980388622 creator A5051963794 @default.
• W1980388622 creator A5060088290 @default.
• W1980388622 date "1997-12-15" @default.
• W1980388622 modified "2023-09-26" @default.
• W1980388622 title "Defining the optimal spacing between repeat radioantibody doses in experimental models" @default.
• W1980388622 cites W1499837259 @default.
• W1980388622 cites W1590042948 @default.
• W1980388622 cites W1921442655 @default.
• W1980388622 cites W1973029769 @default.
• W1980388622 cites W1976520588 @default.
• W1980388622 cites W1990942696 @default.
• W1980388622 cites W2007279899 @default.
• W1980388622 cites W2014995072 @default.
• W1980388622 cites W2041467360 @default.
• W1980388622 cites W2060519872 @default.
• W1980388622 cites W2060847935 @default.
• W1980388622 cites W2067829451 @default.
• W1980388622 cites W2078860796 @default.
• W1980388622 cites W2094826631 @default.
• W1980388622 cites W2098530922 @default.
• W1980388622 cites W2104889636 @default.
• W1980388622 cites W2127920530 @default.
• W1980388622 cites W2152324427 @default.
• W1980388622 cites W2156456116 @default.
• W1980388622 cites W2318431083 @default.
• W1980388622 cites W2412452782 @default.
• W1980388622 cites W2413566034 @default.
• W1980388622 cites W2416128265 @default.
• W1980388622 cites W4239084925 @default.
• W1980388622 cites W4253032163 @default.
• W1980388622 cites W950059845 @default.
• W1980388622 cites W2160078628 @default.
• W1980388622 doi "https://doi.org/10.1002/(sici)1097-0142(19971215)80:12+<2624::aid-cncr38>3.0.co;2-c" @default.
• W1980388622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9406717" @default.
• W1980388622 hasPublicationYear "1997" @default.
• W1980388622 type Work @default.
• W1980388622 sameAs 1980388622 @default.
• W1980388622 citedByCount "5" @default.
• W1980388622 crossrefType "journal-article" @default.
• W1980388622 hasAuthorship W1980388622A5003890903 @default.
• W1980388622 hasAuthorship W1980388622A5005893482 @default.
• W1980388622 hasAuthorship W1980388622A5043569662 @default.
• W1980388622 hasAuthorship W1980388622A5051963794 @default.
• W1980388622 hasAuthorship W1980388622A5060088290 @default.
• W1980388622 hasConcept C121608353 @default.
• W1980388622 hasConcept C126322002 @default.
• W1980388622 hasConcept C159654299 @default.
• W1980388622 hasConcept C16685009 @default.
• W1980388622 hasConcept C203014093 @default.
• W1980388622 hasConcept C2777387746 @default.
• W1980388622 hasConcept C2777761686 @default.
• W1980388622 hasConcept C71924100 @default.
• W1980388622 hasConceptScore W1980388622C121608353 @default.
• W1980388622 hasConceptScore W1980388622C126322002 @default.
• W1980388622 hasConceptScore W1980388622C159654299 @default.
• W1980388622 hasConceptScore W1980388622C16685009 @default.
• W1980388622 hasConceptScore W1980388622C203014093 @default.
• W1980388622 hasConceptScore W1980388622C2777387746 @default.
• W1980388622 hasConceptScore W1980388622C2777761686 @default.
• W1980388622 hasConceptScore W1980388622C71924100 @default.
• W1980388622 hasLocation W19803886221 @default.
• W1980388622 hasLocation W19803886222 @default.
• W1980388622 hasOpenAccess W1980388622 @default.
• W1980388622 hasPrimaryLocation W19803886221 @default.
• W1980388622 hasRelatedWork W2030611884 @default.
• W1980388622 hasRelatedWork W2044307958 @default.
• W1980388622 hasRelatedWork W2046459811 @default.
• W1980388622 hasRelatedWork W2055309949 @default.
• W1980388622 hasRelatedWork W2055899216 @default.
• W1980388622 hasRelatedWork W2090531156 @default.
• W1980388622 hasRelatedWork W2417782082 @default.
• W1980388622 hasRelatedWork W2468120481 @default.
• W1980388622 hasRelatedWork W1556740626 @default.
• W1980388622 hasRelatedWork W2420606421 @default.
• W1980388622 isParatext "false" @default.
• W1980388622 isRetracted "false" @default.
• W1980388622 magId "1980388622" @default.
• W1980388622 workType "article" @default.