FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980415335> ?p ?o ?g. }

• W1980415335 abstract "Serial analysis of gene expression (SAGE) is used to obtain quantitative snapshots of the transcriptome. These profiles are count-based and are assumed to follow a Binomial or Poisson distribution. However, tag counts observed across multiple libraries (for example, one or more groups of biological replicates) have additional variance that cannot be accommodated by this assumption alone. Several models have been proposed to account for this effect, all of which utilize a continuous prior distribution to explain the excess variance. Here, a Poisson mixture model, which assumes excess variability arises from sampling a mixture of distinct components, is proposed and the merits of this model are discussed and evaluated.The goodness of fit of the Poisson mixture model on 15 sets of biological SAGE replicates is compared to the previously proposed hierarchical gamma-Poisson (negative binomial) model, and a substantial improvement is seen. In further support of the mixture model, there is observed: 1) an increase in the number of mixture components needed to fit the expression of tags representing more than one transcript; and 2) a tendency for components to cluster libraries into the same groups. A confidence score is presented that can identify tags that are differentially expressed between groups of SAGE libraries. Several examples where this test outperforms those previously proposed are highlighted.The Poisson mixture model performs well as a) a method to represent SAGE data from biological replicates, and b) a basis to assign significance when testing for differential expression between multiple groups of replicates. Code for the R statistical software package is included to assist investigators in applying this model to their own data." @default.
• W1980415335 created "2016-06-24" @default.
• W1980415335 creator A5070438389 @default.
• W1980415335 date "2007-08-02" @default.
• W1980415335 modified "2023-10-14" @default.
• W1980415335 title "Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model" @default.
• W1980415335 cites W1497616403 @default.
• W1980415335 cites W1509684938 @default.
• W1980415335 cites W1513618424 @default.
• W1980415335 cites W1518650474 @default.
• W1980415335 cites W1549060837 @default.
• W1980415335 cites W1596017741 @default.
• W1980415335 cites W1793647354 @default.
• W1980415335 cites W1974657780 @default.
• W1980415335 cites W1994833998 @default.
• W1980415335 cites W2002982210 @default.
• W1980415335 cites W2020541351 @default.
• W1980415335 cites W2040842187 @default.
• W1980415335 cites W2049633694 @default.
• W1980415335 cites W2112627990 @default.
• W1980415335 cites W2122889787 @default.
• W1980415335 cites W2129164843 @default.
• W1980415335 cites W2133203904 @default.
• W1980415335 cites W2142635246 @default.
• W1980415335 cites W2144264159 @default.
• W1980415335 cites W2151253576 @default.
• W1980415335 cites W2168175751 @default.
• W1980415335 cites W2488678869 @default.
• W1980415335 cites W4213387068 @default.
• W1980415335 doi "https://doi.org/10.1186/1471-2105-8-282" @default.
• W1980415335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2147036" @default.
• W1980415335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17683533" @default.
• W1980415335 hasPublicationYear "2007" @default.
• W1980415335 type Work @default.
• W1980415335 sameAs 1980415335 @default.
• W1980415335 citedByCount "12" @default.
• W1980415335 countsByYear W19804153352012 @default.
• W1980415335 countsByYear W19804153352013 @default.
• W1980415335 countsByYear W19804153352015 @default.
• W1980415335 countsByYear W19804153352016 @default.
• W1980415335 crossrefType "journal-article" @default.
• W1980415335 hasAuthorship W1980415335A5070438389 @default.
• W1980415335 hasBestOaLocation W19804153351 @default.
• W1980415335 hasConcept C100906024 @default.
• W1980415335 hasConcept C105795698 @default.
• W1980415335 hasConcept C114289077 @default.
• W1980415335 hasConcept C121955636 @default.
• W1980415335 hasConcept C132480984 @default.
• W1980415335 hasConcept C144024400 @default.
• W1980415335 hasConcept C144133560 @default.
• W1980415335 hasConcept C148444598 @default.
• W1980415335 hasConcept C149923435 @default.
• W1980415335 hasConcept C196083921 @default.
• W1980415335 hasConcept C199335787 @default.
• W1980415335 hasConcept C199360897 @default.
• W1980415335 hasConcept C2908647359 @default.
• W1980415335 hasConcept C33643355 @default.
• W1980415335 hasConcept C33923547 @default.
• W1980415335 hasConcept C41008148 @default.
• W1980415335 hasConcept C41054675 @default.
• W1980415335 hasConcept C61224824 @default.
• W1980415335 hasConcept C73269764 @default.
• W1980415335 hasConcept C87007009 @default.
• W1980415335 hasConcept C90559484 @default.
• W1980415335 hasConcept C91025261 @default.
• W1980415335 hasConceptScore W1980415335C100906024 @default.
• W1980415335 hasConceptScore W1980415335C105795698 @default.
• W1980415335 hasConceptScore W1980415335C114289077 @default.
• W1980415335 hasConceptScore W1980415335C121955636 @default.
• W1980415335 hasConceptScore W1980415335C132480984 @default.
• W1980415335 hasConceptScore W1980415335C144024400 @default.
• W1980415335 hasConceptScore W1980415335C144133560 @default.
• W1980415335 hasConceptScore W1980415335C148444598 @default.
• W1980415335 hasConceptScore W1980415335C149923435 @default.
• W1980415335 hasConceptScore W1980415335C196083921 @default.
• W1980415335 hasConceptScore W1980415335C199335787 @default.
• W1980415335 hasConceptScore W1980415335C199360897 @default.
• W1980415335 hasConceptScore W1980415335C2908647359 @default.
• W1980415335 hasConceptScore W1980415335C33643355 @default.
• W1980415335 hasConceptScore W1980415335C33923547 @default.
• W1980415335 hasConceptScore W1980415335C41008148 @default.
• W1980415335 hasConceptScore W1980415335C41054675 @default.
• W1980415335 hasConceptScore W1980415335C61224824 @default.
• W1980415335 hasConceptScore W1980415335C73269764 @default.
• W1980415335 hasConceptScore W1980415335C87007009 @default.
• W1980415335 hasConceptScore W1980415335C90559484 @default.
• W1980415335 hasConceptScore W1980415335C91025261 @default.
• W1980415335 hasIssue "1" @default.
• W1980415335 hasLocation W19804153351 @default.
• W1980415335 hasLocation W19804153352 @default.
• W1980415335 hasLocation W19804153353 @default.
• W1980415335 hasLocation W19804153354 @default.
• W1980415335 hasOpenAccess W1980415335 @default.
• W1980415335 hasPrimaryLocation W19804153351 @default.
• W1980415335 hasRelatedWork W1605500305 @default.
• W1980415335 hasRelatedWork W1980415335 @default.
• W1980415335 hasRelatedWork W2018663795 @default.
• W1980415335 hasRelatedWork W2057614015 @default.
• W1980415335 hasRelatedWork W2106389382 @default.
• W1980415335 hasRelatedWork W2129537379 @default.

• next