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- W1980419611 abstract "The neurotoxin 6-hydroxydopamine (6-OHDA) is reported to selectively ablate neurons which contain catecholamines. Leeches were injected with 6-OHDA over a 4-month period in an attempt to destroy their identified dopamine neurons. Ganglionic Retzius cells (RZ), which contain serotonin, were the first to be rendered brown, misshapen, and non-fluorescent. Continued injections of 6-OHDA had similar, but less substantial, morphological and histochemical effects on the dopamine-containing neurosomata within the anterior roots. Toxin treatment reduced RZ serotonin by 75-90%, but these depleted cells retained normal electrophysiological properties. Serotonin and dopamine within ganglia, as well as dopamine within anterior roots, were reduced significantly by 6-OHDA." @default.
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- W1980419611 date "1984-12-01" @default.
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- W1980419611 title "6-Hydroxydopamine produces lesions of serotonin-containing Retzius cells in the leech nervous system" @default.
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- W1980419611 doi "https://doi.org/10.1016/0006-8993(84)90309-3" @default.
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