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- W1980440346 abstract "A 53-year-old man died of sporadic Creutzfeldt-Jakob disease (CJD) after a 1.5-year clinical course. Four and a half years later, his then 55-year-old widow died from CJD after a 1-month illness. Both patients had typical clinical and neuropathologic features of the disease, and pathognomonic proteinase-resistant amyloid protein (prion protein, or PrP) was present in both brains. Neither patient had a family history of neurologic disease, and molecular genetic analysis of their PrP genes was normal. No medical, surgical, or dietary antecedent of CJD was identified; therefore, we are left with the unanswerable alternatives of human-to-human transmission or the chance occurrence of sporadic CJD in a husband and wife." @default.
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- W1980440346 date "1998-03-01" @default.
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- W1980440346 title "Creutzfeldt-Jakob disease in a husband and wife" @default.
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- W1980440346 doi "https://doi.org/10.1212/wnl.50.3.684" @default.
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