Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980442005> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1980442005 abstract "Voltage-dependent Ca2+ channels of fura-2-loaded ganglionic cells from the myenteric plexus of newborn rats were pharmacologically characterised. In contrast to completely dissociated myenteric cells, intact ganglia showed a stronger loading with the Ca2+-sensitive dye and a reproducible stimulation of the fura-2 signal by the cholinergic agonist, carbachol. A depolarisation-induced increase in the intracellular Ca2+ concentration ([Ca2+]i) was induced by superfusion with 35 mmol l(-1) KCl. This increase in [Ca2+]i was sensitive to Ni2+ and Co2+ as well as omega-conotoxin MVIIA, omega-agatoxin IVA, and SNX-482. The strongest inhibition was achieved by nifedipine (5 x 10(-7) mol l(-1)) and omega-conotoxin GVIA (4.3 x 10(-7) mol l(-1)). These two blockers also inhibited the [Ca2+]i increase evoked by nicotinic receptor stimulation. Consequently, isolated myenteric ganglia in culture express different types of voltage-dependent Ca2+ channels, from which the L- and the N-type seem to be the most important. When exposed to mediators of inflammation such as tumor necrosis factor-alpha (TNF-alpha) or different prostaglandins, no pronounced alterations in the fura-2 ratio were observed suggesting that changes in the Ca2+-signalling are not centrally involved in the response of enteric ganglionic cells to these paracrine substances." @default.
- W1980442005 created "2016-06-24" @default.
- W1980442005 creator A5001275179 @default.
- W1980442005 creator A5075282190 @default.
- W1980442005 date "2005-09-01" @default.
- W1980442005 modified "2023-09-24" @default.
- W1980442005 title "Pharmacological characterisation of voltage-dependent Ca2+ channels in isolated ganglia from the myenteric plexus" @default.
- W1980442005 cites W1977921752 @default.
- W1980442005 cites W1995047056 @default.
- W1980442005 cites W1999006690 @default.
- W1980442005 cites W2003663903 @default.
- W1980442005 cites W2022103979 @default.
- W1980442005 cites W2030370100 @default.
- W1980442005 cites W2037048878 @default.
- W1980442005 cites W2037378018 @default.
- W1980442005 cites W2043825278 @default.
- W1980442005 cites W2050543253 @default.
- W1980442005 cites W2057199764 @default.
- W1980442005 cites W2078144575 @default.
- W1980442005 cites W2080266577 @default.
- W1980442005 cites W2086313302 @default.
- W1980442005 cites W2141260882 @default.
- W1980442005 cites W2145510836 @default.
- W1980442005 cites W2147381068 @default.
- W1980442005 cites W2174796795 @default.
- W1980442005 cites W2417649616 @default.
- W1980442005 cites W2912991414 @default.
- W1980442005 doi "https://doi.org/10.1016/j.lfs.2004.12.053" @default.
- W1980442005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15990120" @default.
- W1980442005 hasPublicationYear "2005" @default.
- W1980442005 type Work @default.
- W1980442005 sameAs 1980442005 @default.
- W1980442005 citedByCount "3" @default.
- W1980442005 crossrefType "journal-article" @default.
- W1980442005 hasAuthorship W1980442005A5001275179 @default.
- W1980442005 hasAuthorship W1980442005A5075282190 @default.
- W1980442005 hasConcept C126322002 @default.
- W1980442005 hasConcept C134018914 @default.
- W1980442005 hasConcept C170493617 @default.
- W1980442005 hasConcept C185592680 @default.
- W1980442005 hasConcept C18699975 @default.
- W1980442005 hasConcept C204232928 @default.
- W1980442005 hasConcept C22885893 @default.
- W1980442005 hasConcept C24998067 @default.
- W1980442005 hasConcept C2776907353 @default.
- W1980442005 hasConcept C2778938600 @default.
- W1980442005 hasConcept C2778988552 @default.
- W1980442005 hasConcept C2779066535 @default.
- W1980442005 hasConcept C4141045 @default.
- W1980442005 hasConcept C519063684 @default.
- W1980442005 hasConcept C71924100 @default.
- W1980442005 hasConcept C86803240 @default.
- W1980442005 hasConceptScore W1980442005C126322002 @default.
- W1980442005 hasConceptScore W1980442005C134018914 @default.
- W1980442005 hasConceptScore W1980442005C170493617 @default.
- W1980442005 hasConceptScore W1980442005C185592680 @default.
- W1980442005 hasConceptScore W1980442005C18699975 @default.
- W1980442005 hasConceptScore W1980442005C204232928 @default.
- W1980442005 hasConceptScore W1980442005C22885893 @default.
- W1980442005 hasConceptScore W1980442005C24998067 @default.
- W1980442005 hasConceptScore W1980442005C2776907353 @default.
- W1980442005 hasConceptScore W1980442005C2778938600 @default.
- W1980442005 hasConceptScore W1980442005C2778988552 @default.
- W1980442005 hasConceptScore W1980442005C2779066535 @default.
- W1980442005 hasConceptScore W1980442005C4141045 @default.
- W1980442005 hasConceptScore W1980442005C519063684 @default.
- W1980442005 hasConceptScore W1980442005C71924100 @default.
- W1980442005 hasConceptScore W1980442005C86803240 @default.
- W1980442005 hasLocation W19804420051 @default.
- W1980442005 hasLocation W19804420052 @default.
- W1980442005 hasOpenAccess W1980442005 @default.
- W1980442005 hasPrimaryLocation W19804420051 @default.
- W1980442005 hasRelatedWork W1976266702 @default.
- W1980442005 hasRelatedWork W1980442005 @default.
- W1980442005 hasRelatedWork W1989594914 @default.
- W1980442005 hasRelatedWork W2028553251 @default.
- W1980442005 hasRelatedWork W2036359153 @default.
- W1980442005 hasRelatedWork W2042034200 @default.
- W1980442005 hasRelatedWork W2045166937 @default.
- W1980442005 hasRelatedWork W2082649292 @default.
- W1980442005 hasRelatedWork W2106101717 @default.
- W1980442005 hasRelatedWork W2034873296 @default.
- W1980442005 isParatext "false" @default.
- W1980442005 isRetracted "false" @default.
- W1980442005 magId "1980442005" @default.
- W1980442005 workType "article" @default.