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• W1980462725 abstract "This editorial commentary discusses the problems and limitations of providing combination antiretroviral therapy (cART) to HIV-infected children in resource-limited countries. In such countries over 60% of HIV-infected children die prior to their third birthday. At the end of 2007 2.5 million children were estimated to be living with HIV infection and about 420000 continue to be newly infected yearly primarily in low-resource countries through mother to child transmission (MTCT) of HIV. Despite slow progress in implementing pediatric treatment programs there have been numerous publications that demonstrate that HIV-infected children in resource-limited countries respond to cART as well as children in resource-rich countries and that implementation of treatment programs for large numbers of children can be accomplished in such settings despite multiple challenges. However the issue of which cART regimen to start in HIV-infected infants is problematic as there is a limited pediatric drug formulary. The commentary refers to a study published in the same issue that adds to a growing body of evidence suggesting that good clinical outcomes can be obtained in African HIV-infected children treated with cART even in decentralized primary healthcare facilities. (excerpt)" @default.
• W1980462725 created "2016-06-24" @default.
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• W1980462725 date "2008-07-11" @default.
• W1980462725 modified "2023-09-28" @default.
• W1980462725 title "Early antiretroviral therapy of HIV-infected infants in resource-limited countries: possible, feasible, effective and challenging" @default.
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• W1980462725 doi "https://doi.org/10.1097/qad.0b013e32830437f5" @default.
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