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• W1980472443 endingPage "1441" @default.
• W1980472443 startingPage "1434" @default.
• W1980472443 abstract "Neuroimaging methods such as functional magnetic resonance imaging (fMRI) have been used extensively to investigate pain-related cerebral mechanisms. However, these methods rely on a tight coupling of neuronal activity to hemodynamic changes. Because pain may be associated with hemodynamic changes unrelated to local neuronal activity (eg, increased mean arterial pressure [MAP]), it is essential to determine whether the neurovascular coupling is maintained during nociceptive processing. In this study, local field potentials (LFP) and cortical blood flow (CBF) changes evoked by electrical stimulation of the left hind paw were recorded concomitantly in the right primary somatosensory cortex (SI) in 15 rats. LFP, CBF, and MAP changes were examined in response to stimulus intensities ranging from 3 to 30 mA. In addition, LFP, CBF, and MAP changes evoked by a 10-mA stimulation were examined during immersion of the tail in non-nociceptive or nociceptive hot water (counter-stimulation). SI neurovascular coupling was altered for stimuli of nociceptive intensities (P<0.001). This alteration was intensity-dependent and was strongly associated with MAP changes (r=0.98, P<0.001). However, when the stimulus intensity was kept constant, SI neurovascular coupling was not significantly affected by nociceptive counter-stimulation (P=0.4), which similarly affected the amplitude of shock-evoked LFP and CBF changes. It remains to be determined whether such neurovascular uncoupling occurs in humans, and whether it also affects other regions usually activated by painful stimuli. These results should be taken into account for accurate interpretation of fMRI studies that involve nociceptive stimuli associated with MAP changes." @default.
• W1980472443 created "2016-06-24" @default.
• W1980472443 creator A5014641691 @default.
• W1980472443 creator A5041664319 @default.
• W1980472443 creator A5090919420 @default.
• W1980472443 date "2013-08-01" @default.
• W1980472443 modified "2023-10-14" @default.
• W1980472443 title "Neurovascular coupling during nociceptive processing in the primary somatosensory cortex of the rat" @default.
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• W1980472443 doi "https://doi.org/10.1016/j.pain.2013.04.042" @default.
• W1980472443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23707276" @default.
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