FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980483501> ?p ?o ?g. }

• W1980483501 endingPage "260" @default.
• W1980483501 startingPage "254" @default.
• W1980483501 abstract "The present study aimed to prepare a chemically and physically stable formulation of doxycycline (Doxy) in an in situ thermally sensitive hydrogel for ophthalmic delivery. An inclusion complex of Doxy and hydroxypropyl-β-cyclodextrin (HP-β-CD) was first developed to increase the stability of Doxy in aqueous solution. The physical characteristics (phase solubility profiles, thermal analysis, X-ray powder diffractograms and infrared spectra) of the Doxy-HP-β-CD inclusion complex indicated the formation of a stable 1:1 complex. Poloxamers P407 (16–22%) and P188 (0–5%) were mixed to obtain a hydrogel with an appropriate gelation temperature for opthalmic use. Formulation of the inclusion complex in the poloxamer hydrogel exhibited a suitable gelation temperature (33.3 °C) after dilution with simulated tear fluid (Gel:STF=40:7, v/v). The release of Doxy from the poloxamer hydrogel followed a zero order equation suggesting it occurs through corrosion of the poloxamer hydrogel. Stability studies demonstrated that the inclusion of Doxy by HP-β-CD markedly improved its stability in aqueous solution both at 8 and 40 °C. This formulation of a doxycycline-HP-β-CD inclusion complex in an in situ thermally sensitive poloxamer hydrogel represents a potentially effective ophthalmic Doxy delivery system." @default.
• W1980483501 created "2016-06-24" @default.
• W1980483501 creator A5017563434 @default.
• W1980483501 creator A5030536277 @default.
• W1980483501 creator A5031699022 @default.
• W1980483501 creator A5044053727 @default.
• W1980483501 creator A5070892641 @default.
• W1980483501 creator A5086247223 @default.
• W1980483501 creator A5089480544 @default.
• W1980483501 date "2011-12-01" @default.
• W1980483501 modified "2023-10-07" @default.
• W1980483501 title "Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery" @default.
• W1980483501 cites W1527844977 @default.
• W1980483501 cites W176812056 @default.
• W1980483501 cites W1966590541 @default.
• W1980483501 cites W1968256243 @default.
• W1980483501 cites W1976236482 @default.
• W1980483501 cites W1993951343 @default.
• W1980483501 cites W1995488266 @default.
• W1980483501 cites W2001015862 @default.
• W1980483501 cites W2004165733 @default.
• W1980483501 cites W2011291830 @default.
• W1980483501 cites W2030817962 @default.
• W1980483501 cites W2036678453 @default.
• W1980483501 cites W2037411825 @default.
• W1980483501 cites W2054016731 @default.
• W1980483501 cites W2058509094 @default.
• W1980483501 cites W2059841560 @default.
• W1980483501 cites W2072153975 @default.
• W1980483501 cites W2086130473 @default.
• W1980483501 cites W2092838342 @default.
• W1980483501 cites W2117798770 @default.
• W1980483501 cites W2136348600 @default.
• W1980483501 cites W276174135 @default.
• W1980483501 doi "https://doi.org/10.1016/j.apsb.2011.10.004" @default.
• W1980483501 hasPublicationYear "2011" @default.
• W1980483501 type Work @default.
• W1980483501 sameAs 1980483501 @default.
• W1980483501 citedByCount "59" @default.
• W1980483501 countsByYear W19804835012012 @default.
• W1980483501 countsByYear W19804835012013 @default.
• W1980483501 countsByYear W19804835012014 @default.
• W1980483501 countsByYear W19804835012015 @default.
• W1980483501 countsByYear W19804835012016 @default.
• W1980483501 countsByYear W19804835012017 @default.
• W1980483501 countsByYear W19804835012018 @default.
• W1980483501 countsByYear W19804835012019 @default.
• W1980483501 countsByYear W19804835012020 @default.
• W1980483501 countsByYear W19804835012021 @default.
• W1980483501 countsByYear W19804835012022 @default.
• W1980483501 countsByYear W19804835012023 @default.
• W1980483501 crossrefType "journal-article" @default.
• W1980483501 hasAuthorship W1980483501A5017563434 @default.
• W1980483501 hasAuthorship W1980483501A5030536277 @default.
• W1980483501 hasAuthorship W1980483501A5031699022 @default.
• W1980483501 hasAuthorship W1980483501A5044053727 @default.
• W1980483501 hasAuthorship W1980483501A5070892641 @default.
• W1980483501 hasAuthorship W1980483501A5086247223 @default.
• W1980483501 hasAuthorship W1980483501A5089480544 @default.
• W1980483501 hasBestOaLocation W19804835011 @default.
• W1980483501 hasConcept C101335993 @default.
• W1980483501 hasConcept C127413603 @default.
• W1980483501 hasConcept C13965031 @default.
• W1980483501 hasConcept C155574463 @default.
• W1980483501 hasConcept C15920480 @default.
• W1980483501 hasConcept C178790620 @default.
• W1980483501 hasConcept C184651966 @default.
• W1980483501 hasConcept C185592680 @default.
• W1980483501 hasConcept C192562407 @default.
• W1980483501 hasConcept C2777179404 @default.
• W1980483501 hasConcept C2779433975 @default.
• W1980483501 hasConcept C2780306666 @default.
• W1980483501 hasConcept C2910962261 @default.
• W1980483501 hasConcept C42360764 @default.
• W1980483501 hasConcept C43617362 @default.
• W1980483501 hasConcept C501593827 @default.
• W1980483501 hasConcept C521977710 @default.
• W1980483501 hasConcept C55493867 @default.
• W1980483501 hasConcept C59061564 @default.
• W1980483501 hasConcept C88380143 @default.
• W1980483501 hasConceptScore W1980483501C101335993 @default.
• W1980483501 hasConceptScore W1980483501C127413603 @default.
• W1980483501 hasConceptScore W1980483501C13965031 @default.
• W1980483501 hasConceptScore W1980483501C155574463 @default.
• W1980483501 hasConceptScore W1980483501C15920480 @default.
• W1980483501 hasConceptScore W1980483501C178790620 @default.
• W1980483501 hasConceptScore W1980483501C184651966 @default.
• W1980483501 hasConceptScore W1980483501C185592680 @default.
• W1980483501 hasConceptScore W1980483501C192562407 @default.
• W1980483501 hasConceptScore W1980483501C2777179404 @default.
• W1980483501 hasConceptScore W1980483501C2779433975 @default.
• W1980483501 hasConceptScore W1980483501C2780306666 @default.
• W1980483501 hasConceptScore W1980483501C2910962261 @default.
• W1980483501 hasConceptScore W1980483501C42360764 @default.
• W1980483501 hasConceptScore W1980483501C43617362 @default.
• W1980483501 hasConceptScore W1980483501C501593827 @default.
• W1980483501 hasConceptScore W1980483501C521977710 @default.
• W1980483501 hasConceptScore W1980483501C55493867 @default.

• next