Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980488313> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1980488313 abstract "The effect of calcium channel blocking agents on the reductive metabolism of halothane in liver microsomes of guinea pigs was investigated. The reaction mixture for the measurement of the end products consisted of microsomal suspension, 5 mM NADPH, calcium channel blocking agents (verapamil, diltiazem, nicardipine and nifedipine) and halothane in 0.1 M phosphate buffer (pH 7.4). The reductive metabolism of halothane was inhibited competitively by verapamil, diltiazem and nicardipine. The binding spectra for the interaction of these three drugs with cytochrome P-450 in microsomes were investigated. Verapamil caused the reverse type I difference spectrum and diltiazem caused the type I difference spectrum. However, the change caused by nicardipine was not observed by the presence of its specific spectra. NADPH-cytochrome P-450 reductase activity in microsomes did not change by the addition of these three drugs. These results suggest that these three calcium channel blocking agents inhibit the production of radical intermediates during the reductive metabolism of halothane." @default.
- W1980488313 created "2016-06-24" @default.
- W1980488313 creator A5035847003 @default.
- W1980488313 creator A5043204128 @default.
- W1980488313 creator A5046459798 @default.
- W1980488313 creator A5060907582 @default.
- W1980488313 date "1991-02-01" @default.
- W1980488313 modified "2023-09-27" @default.
- W1980488313 title "Effect of calcium channel blocking agents on the reductive metabolism of halothane" @default.
- W1980488313 cites W1775749144 @default.
- W1980488313 cites W1951469402 @default.
- W1980488313 cites W1988278312 @default.
- W1980488313 cites W1992463039 @default.
- W1980488313 cites W1992490604 @default.
- W1980488313 cites W1994032728 @default.
- W1980488313 cites W2056196711 @default.
- W1980488313 cites W2071899992 @default.
- W1980488313 cites W2120944108 @default.
- W1980488313 doi "https://doi.org/10.1002/jat.2550110106" @default.
- W1980488313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1902495" @default.
- W1980488313 hasPublicationYear "1991" @default.
- W1980488313 type Work @default.
- W1980488313 sameAs 1980488313 @default.
- W1980488313 citedByCount "0" @default.
- W1980488313 crossrefType "journal-article" @default.
- W1980488313 hasAuthorship W1980488313A5035847003 @default.
- W1980488313 hasAuthorship W1980488313A5043204128 @default.
- W1980488313 hasAuthorship W1980488313A5046459798 @default.
- W1980488313 hasAuthorship W1980488313A5060907582 @default.
- W1980488313 hasConcept C178790620 @default.
- W1980488313 hasConcept C181199279 @default.
- W1980488313 hasConcept C185592680 @default.
- W1980488313 hasConcept C2776741139 @default.
- W1980488313 hasConcept C2776932660 @default.
- W1980488313 hasConcept C2777022698 @default.
- W1980488313 hasConcept C2778043224 @default.
- W1980488313 hasConcept C2779066535 @default.
- W1980488313 hasConcept C519063684 @default.
- W1980488313 hasConcept C55493867 @default.
- W1980488313 hasConcept C62231903 @default.
- W1980488313 hasConcept C71924100 @default.
- W1980488313 hasConcept C85520022 @default.
- W1980488313 hasConcept C87644729 @default.
- W1980488313 hasConcept C98274493 @default.
- W1980488313 hasConceptScore W1980488313C178790620 @default.
- W1980488313 hasConceptScore W1980488313C181199279 @default.
- W1980488313 hasConceptScore W1980488313C185592680 @default.
- W1980488313 hasConceptScore W1980488313C2776741139 @default.
- W1980488313 hasConceptScore W1980488313C2776932660 @default.
- W1980488313 hasConceptScore W1980488313C2777022698 @default.
- W1980488313 hasConceptScore W1980488313C2778043224 @default.
- W1980488313 hasConceptScore W1980488313C2779066535 @default.
- W1980488313 hasConceptScore W1980488313C519063684 @default.
- W1980488313 hasConceptScore W1980488313C55493867 @default.
- W1980488313 hasConceptScore W1980488313C62231903 @default.
- W1980488313 hasConceptScore W1980488313C71924100 @default.
- W1980488313 hasConceptScore W1980488313C85520022 @default.
- W1980488313 hasConceptScore W1980488313C87644729 @default.
- W1980488313 hasConceptScore W1980488313C98274493 @default.
- W1980488313 hasLocation W19804883131 @default.
- W1980488313 hasLocation W19804883132 @default.
- W1980488313 hasOpenAccess W1980488313 @default.
- W1980488313 hasPrimaryLocation W19804883131 @default.
- W1980488313 hasRelatedWork W1965546722 @default.
- W1980488313 hasRelatedWork W1980488313 @default.
- W1980488313 hasRelatedWork W2018149109 @default.
- W1980488313 hasRelatedWork W2020275754 @default.
- W1980488313 hasRelatedWork W2076436346 @default.
- W1980488313 hasRelatedWork W2079879029 @default.
- W1980488313 hasRelatedWork W2148282970 @default.
- W1980488313 hasRelatedWork W2414315321 @default.
- W1980488313 hasRelatedWork W2460117155 @default.
- W1980488313 hasRelatedWork W324290327 @default.
- W1980488313 isParatext "false" @default.
- W1980488313 isRetracted "false" @default.
- W1980488313 magId "1980488313" @default.
- W1980488313 workType "article" @default.