Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980538082> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1980538082 endingPage "950" @default.
- W1980538082 startingPage "945" @default.
- W1980538082 abstract "Stimulators of bone resorption, such as PTH, 25-dihydroxycholecalciferol [1,25-(OH)2D3], or prostaglandin E2 (PGE2), do not cause calcium release from cultured calvaria of the genetically determined osteopetrotic microphthalmic (mi/ mi) mouse, due to a defect in the function of osteoclasts. To investigate the capacity of cells of mi/mi bone to degrade collagen, calvaria of 1- to 3-day-old normal and mi/mi littermates were labeled in vivo with [3H]proline 16 h before removal, followed by culture in resorption medium. PTH, 1,25-(OH)2D3, and PGE2 stimulated the release of 3H-labeled material into the culture medium from both normal and mi/mi calvaria. The labeled substance released was of collagenous origin, as indicated by its content of hydroxyproline and susceptibility to collagenase. PTH also stimulated the release of 3H-labeled materials from normal calvaria labeled in vivo 112 h before the mice were killed, but had little or no effect on 3H release from the mi/mibone, indicating that only noncalcified collagen is susceptible to hormone-stimulated degradation in osteopetrotic bone. We conclude that a portion of the hormone-stimulated resorptive mechanism, namely collagenolysis, is functional in bone of mi/mi mice. This result helps to pinpoint the resorptive defect in mi/ mi bone to a failure to dissolve mineral, rather than a more general phenomenon of failure to remove both mineral and matrix." @default.
- W1980538082 created "2016-06-24" @default.
- W1980538082 creator A5011446671 @default.
- W1980538082 creator A5072399138 @default.
- W1980538082 date "1983-03-01" @default.
- W1980538082 modified "2023-09-25" @default.
- W1980538082 title "A Collagenolytic Response to Parathormone, 1,25-Dihydroxycholecalciferol D3, and Prostaglandin E2in Bone of Osteopetrotic (mi/mi) Mice*" @default.
- W1980538082 cites W1983228126 @default.
- W1980538082 cites W1991827538 @default.
- W1980538082 cites W2009071266 @default.
- W1980538082 cites W2009904653 @default.
- W1980538082 cites W2024998533 @default.
- W1980538082 cites W2025477745 @default.
- W1980538082 cites W2029778117 @default.
- W1980538082 cites W2041928773 @default.
- W1980538082 cites W2071990130 @default.
- W1980538082 cites W2072233286 @default.
- W1980538082 cites W2082790101 @default.
- W1980538082 cites W2086636882 @default.
- W1980538082 cites W2088369023 @default.
- W1980538082 cites W2088732407 @default.
- W1980538082 cites W2090228410 @default.
- W1980538082 cites W2134689541 @default.
- W1980538082 cites W2156229972 @default.
- W1980538082 cites W2166549790 @default.
- W1980538082 cites W2443980846 @default.
- W1980538082 doi "https://doi.org/10.1210/endo-112-3-945" @default.
- W1980538082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6571820" @default.
- W1980538082 hasPublicationYear "1983" @default.
- W1980538082 type Work @default.
- W1980538082 sameAs 1980538082 @default.
- W1980538082 citedByCount "24" @default.
- W1980538082 countsByYear W19805380822020 @default.
- W1980538082 crossrefType "journal-article" @default.
- W1980538082 hasAuthorship W1980538082A5011446671 @default.
- W1980538082 hasAuthorship W1980538082A5072399138 @default.
- W1980538082 hasBestOaLocation W19805380821 @default.
- W1980538082 hasConcept C126322002 @default.
- W1980538082 hasConcept C134018914 @default.
- W1980538082 hasConcept C146562846 @default.
- W1980538082 hasConcept C150903083 @default.
- W1980538082 hasConcept C181199279 @default.
- W1980538082 hasConcept C185592680 @default.
- W1980538082 hasConcept C202751555 @default.
- W1980538082 hasConcept C207001950 @default.
- W1980538082 hasConcept C2778394429 @default.
- W1980538082 hasConcept C2779797417 @default.
- W1980538082 hasConcept C2779918246 @default.
- W1980538082 hasConcept C2781208988 @default.
- W1980538082 hasConcept C519063684 @default.
- W1980538082 hasConcept C55493867 @default.
- W1980538082 hasConcept C673006 @default.
- W1980538082 hasConcept C71924100 @default.
- W1980538082 hasConcept C86803240 @default.
- W1980538082 hasConceptScore W1980538082C126322002 @default.
- W1980538082 hasConceptScore W1980538082C134018914 @default.
- W1980538082 hasConceptScore W1980538082C146562846 @default.
- W1980538082 hasConceptScore W1980538082C150903083 @default.
- W1980538082 hasConceptScore W1980538082C181199279 @default.
- W1980538082 hasConceptScore W1980538082C185592680 @default.
- W1980538082 hasConceptScore W1980538082C202751555 @default.
- W1980538082 hasConceptScore W1980538082C207001950 @default.
- W1980538082 hasConceptScore W1980538082C2778394429 @default.
- W1980538082 hasConceptScore W1980538082C2779797417 @default.
- W1980538082 hasConceptScore W1980538082C2779918246 @default.
- W1980538082 hasConceptScore W1980538082C2781208988 @default.
- W1980538082 hasConceptScore W1980538082C519063684 @default.
- W1980538082 hasConceptScore W1980538082C55493867 @default.
- W1980538082 hasConceptScore W1980538082C673006 @default.
- W1980538082 hasConceptScore W1980538082C71924100 @default.
- W1980538082 hasConceptScore W1980538082C86803240 @default.
- W1980538082 hasIssue "3" @default.
- W1980538082 hasLocation W19805380821 @default.
- W1980538082 hasLocation W19805380822 @default.
- W1980538082 hasOpenAccess W1980538082 @default.
- W1980538082 hasPrimaryLocation W19805380821 @default.
- W1980538082 hasRelatedWork W1885242166 @default.
- W1980538082 hasRelatedWork W1980538082 @default.
- W1980538082 hasRelatedWork W1986049049 @default.
- W1980538082 hasRelatedWork W1990936130 @default.
- W1980538082 hasRelatedWork W2079179424 @default.
- W1980538082 hasRelatedWork W2085190176 @default.
- W1980538082 hasRelatedWork W2085658732 @default.
- W1980538082 hasRelatedWork W2088946921 @default.
- W1980538082 hasRelatedWork W2132718443 @default.
- W1980538082 hasRelatedWork W2161331120 @default.
- W1980538082 hasVolume "112" @default.
- W1980538082 isParatext "false" @default.
- W1980538082 isRetracted "false" @default.
- W1980538082 magId "1980538082" @default.
- W1980538082 workType "article" @default.