FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1980556625> ?p ?o ?g. }

• W1980556625 endingPage "1774" @default.
• W1980556625 startingPage "1761" @default.
• W1980556625 abstract "Although there may be a close relationship between B lymphocytes and osteoclasts, or bone resorbing cells, little is known about the role of B lymphocytes in bone formation. We compared in vivo new bone induction in mice homozygous for the B-cell deficient (microMT) gene knockout, which lack functional B lymphocytes, with bone induction in control wild-type (C57BL/6) mice. Our comparison used two models of new bone induction in vivo: endochondral osteoinduction by subcutaneous implantation of recombinant human bone morphogenetic protein (rhBMP-2) and osteogenic regeneration after tibial bone marrow ablation. The expression of bone-specific proteins (bone sialoprotein, osteopontin, and osteocalcin) and inflammatory/immunomodulatory cytokines (interleukin-1alpha and -1beta, interleukin-6, and tumor necrosis factor-alpha) was assessed by Northern blot analysis or reverse transcription-polymerase chain reaction, respectively. Ossicles induced by rhBMP-2 were larger in volume and mass in microMT knockout mice, but relative volumes of the newly induced bone, cartilage, and bone marrow were similar in the two groups. Six days after tibial bone marrow ablation, microMT knockout mice resorbed the initial blood clot faster and formed more trabecular bone, paralleled by greater levels of bone sialoprotein mRNA than in the wild-type mice. microMT knockout and wild-type mice also differed in the expression pattern of inflammatory/immunomodulatory cytokines during the development of the newly induced bone, suggesting that a genetic lack of B lymphocytes may create a change in the immunological milieu at the site of new bone induction, which stimulates the initial accumulation and proliferation of mesenchymal progenitor." @default.
• W1980556625 created "2016-06-24" @default.
• W1980556625 creator A5002442504 @default.
• W1980556625 creator A5003761640 @default.
• W1980556625 creator A5009128656 @default.
• W1980556625 creator A5046187244 @default.
• W1980556625 creator A5047640338 @default.
• W1980556625 creator A5076199878 @default.
• W1980556625 creator A5091730315 @default.
• W1980556625 date "2000-11-01" @default.
• W1980556625 modified "2023-10-18" @default.
• W1980556625 title "Role of B Lymphocytes in New Bone Formation" @default.
• W1980556625 cites W1499024571 @default.
• W1980556625 cites W1509651969 @default.
• W1980556625 cites W1559018455 @default.
• W1980556625 cites W1566003869 @default.
• W1980556625 cites W1574330564 @default.
• W1980556625 cites W1649547160 @default.
• W1980556625 cites W1972124518 @default.
• W1980556625 cites W1977013832 @default.
• W1980556625 cites W1984767683 @default.
• W1980556625 cites W1988987060 @default.
• W1980556625 cites W1995322582 @default.
• W1980556625 cites W1996028579 @default.
• W1980556625 cites W2006351148 @default.
• W1980556625 cites W2010199883 @default.
• W1980556625 cites W2012999426 @default.
• W1980556625 cites W2015668670 @default.
• W1980556625 cites W2016710605 @default.
• W1980556625 cites W2019037276 @default.
• W1980556625 cites W2026110555 @default.
• W1980556625 cites W2031501484 @default.
• W1980556625 cites W2032348735 @default.
• W1980556625 cites W2036095605 @default.
• W1980556625 cites W2036392890 @default.
• W1980556625 cites W2037735580 @default.
• W1980556625 cites W2039241519 @default.
• W1980556625 cites W2046621497 @default.
• W1980556625 cites W2047504447 @default.
• W1980556625 cites W2049293744 @default.
• W1980556625 cites W2054854767 @default.
• W1980556625 cites W2058106399 @default.
• W1980556625 cites W2063469496 @default.
• W1980556625 cites W2064108441 @default.
• W1980556625 cites W2069141025 @default.
• W1980556625 cites W2070434416 @default.
• W1980556625 cites W2073788939 @default.
• W1980556625 cites W2086793358 @default.
• W1980556625 cites W2087378917 @default.
• W1980556625 cites W2088864696 @default.
• W1980556625 cites W2098359902 @default.
• W1980556625 cites W2125424508 @default.
• W1980556625 cites W2139811906 @default.
• W1980556625 cites W2139996507 @default.
• W1980556625 cites W2340668340 @default.
• W1980556625 doi "https://doi.org/10.1038/labinvest.3780186" @default.
• W1980556625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11092536" @default.
• W1980556625 hasPublicationYear "2000" @default.
• W1980556625 type Work @default.
• W1980556625 sameAs 1980556625 @default.
• W1980556625 citedByCount "45" @default.
• W1980556625 countsByYear W19805566252012 @default.
• W1980556625 countsByYear W19805566252013 @default.
• W1980556625 countsByYear W19805566252014 @default.
• W1980556625 countsByYear W19805566252016 @default.
• W1980556625 countsByYear W19805566252017 @default.
• W1980556625 countsByYear W19805566252018 @default.
• W1980556625 countsByYear W19805566252019 @default.
• W1980556625 countsByYear W19805566252021 @default.
• W1980556625 countsByYear W19805566252022 @default.
• W1980556625 countsByYear W19805566252023 @default.
• W1980556625 crossrefType "journal-article" @default.
• W1980556625 hasAuthorship W1980556625A5002442504 @default.
• W1980556625 hasAuthorship W1980556625A5003761640 @default.
• W1980556625 hasAuthorship W1980556625A5009128656 @default.
• W1980556625 hasAuthorship W1980556625A5046187244 @default.
• W1980556625 hasAuthorship W1980556625A5047640338 @default.
• W1980556625 hasAuthorship W1980556625A5076199878 @default.
• W1980556625 hasAuthorship W1980556625A5091730315 @default.
• W1980556625 hasBestOaLocation W19805566251 @default.
• W1980556625 hasConcept C104317684 @default.
• W1980556625 hasConcept C105702510 @default.
• W1980556625 hasConcept C125349252 @default.
• W1980556625 hasConcept C131075544 @default.
• W1980556625 hasConcept C134018914 @default.
• W1980556625 hasConcept C142724271 @default.
• W1980556625 hasConcept C160160445 @default.
• W1980556625 hasConcept C17938293 @default.
• W1980556625 hasConcept C181199279 @default.
• W1980556625 hasConcept C203014093 @default.
• W1980556625 hasConcept C2776432469 @default.
• W1980556625 hasConcept C2780007613 @default.
• W1980556625 hasConcept C2780550940 @default.
• W1980556625 hasConcept C2780804394 @default.
• W1980556625 hasConcept C31507581 @default.
• W1980556625 hasConcept C55493867 @default.
• W1980556625 hasConcept C71924100 @default.
• W1980556625 hasConcept C86803240 @default.

• next